SEQUENZA DI TERAPIE E STUDIO CONTROLLATO: LO “STEPPED WEDGE TRIAL”. UNA OCCASIONE PER GLI STUDI SUL COVID ? E PER LE MALATTIE AD ORIGINE COMPLESSA COME LE IBD O LA IBS?

Key concepts in clinical epidemiology: Stepped wedge trials Richard Hooper Abstract A stepped wedge trial evaluates an intervention that is implemented over a number of time periods according to a staggered timetable. Stepped wedge trials are usually cluster randomized, the intervention being delivered at some geographical, service or other cluster level. There is considerable variety…

SORVEGLIANZA E GESTIONE DELLA DISPLASIA COLORETTALE IN CORSO DI IBD: UNA REVISIONE AGA DA ESPERTI

AGA Clinical Practice Update on Endoscopic Surveillance and Management of Colorectal Dysplasia in Inflammatory Bowel Diseases: Expert Review Sanjay K. Murthy et al. Improvements in disease management, as well as endoscopic technology and quality, have dramatically changed the way in which we conceptualize and manage inflammatory bowel disease–related dysplasia over the past 20 years. Based…

NNT: PER COMBINARE BENEFICI E RISCHI NASCE “NNT PER EFFETTO NETTO” , UNA STATISTICA INTELLIGENTE DALLA McMASTER !

The number needed to treat for net effect (NNTnet) as a metric for measuring combined benefits and harms Guowei Lia et al. Abstract Calculating the number needed to treat (NNT) has been widely used to help understand treatment effect results of randomized controlled trials (RCTs). Combined benefit and harm profiles from RCT results have to…

PREVENZIONE DELL’HCC CON FANS ED ANTI-AGGREGANTI: UNA GRANDE META-ANALISI DA APT

Systematic review with meta-analysis: The effects of non-steroidal anti-inflammatory drugs and anti-platelet therapy on the incidence and recurrence of hepatocellular carcinoma Regina Zi Hwei Ta et al. Background: Chemoprevention with NSAIDs, including aspirin, and anti-platelet therapy (APT), has been suggested to reduce the incidence and recurrence of hepatocellular carcinoma (HCC). Aim: To determine by meta-analysis whether NSAIDs…

CANCRO DEL PANCREAS: UNA GRANDE REVIEW DA JAMA

Pancreatic Cancer A Review Wungki Park et al. IMPORTANCE Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon cancer, with approximately 60 430 new diagnoses expected in 2021 in the US. The incidence of PDAC is increasing by 0.5% to 1.0% per year, and it is projected to become the second-leading cause of cancer-related mortality by…