RECALL: GLI ANTIDEPRESSIVI SSRI PROVOCANO EMORRAGIA DIGESTIVA: + 36% (12% a 64%). DA “Pharmacological Research” (FREE!)

Bleeding risk under selective serotonin reuptake inhibitor (SSRI) antidepressants: A meta-analysis of observational studies  Silvy Laportea et al. Selective serotonin reuptake inhibitors (SSRIs) have been reported to be potentially associated with an increased risk of bleeding. A meta-analysis of observational studies was conducted to quantify this risk. Case-control and cohort studies investigating bleeding risk under…

COLON IRRITABILE 2: EFFICACIA DELLA DIETA! UNA NUOVA NETWORK META-ANALISI! DA “THE LANCET GASTROENTEROLOGY & HEPATOLOGY”

Efficacy of dietary interventions in irritable bowel syndrome: a systematic review and network meta-analysis Melanie S Cuffe, MBCh et al. Summary Background Patients with irritable bowel syndrome (IBS) are often interested in dietary interventions as a means of managing their symptoms. However, the relative efficacy of available diets for the management of IBS is unclear. We aimed…

COLON IRRITABILE 1 : EFFETTO DEI NEUROMODULATORI ! LA NUOVA META-ANALISI! DA “THE LANCET GASTROENTEROLOGY & HEPATOLOGY”

Efficacy of gut–brain neuromodulators in irritable bowel syndrome: an updated systematic review and meta-analysis Mais Khasawneh, MBBS et al. Summary Background Gut–brain neuromodulators might be efficacious for irritable bowel syndrome (IBS), but there has been no synthesis of evidence from randomised controlled trials (RCTs) of some drug classes, and whether they have pain-modifying properties in…

REGIMI DI CHEMIOTERAPIA PER IL K PANCREAS NON OPERABILE: UNA MAGNIFICA NETWORK META-ANALISI DAL GRUPPO DELLA CATTOLICA DI ROMA. VINCONO NALIRIFOX E FOLFIRINOX. DA “THE LANCET ONCOLOGY” “

Comparison of first-line chemotherapy regimens in unresectable locally advanced or metastatic pancreatic cancer: a systematic review and Bayesian network meta-analysis Luca Mastrantoni et al. Summary Background In advanced pancreatic ductal adenocarcinoma (PDAC), first-line chemotherapy is the standard of care. Due to the absence of head-to-head comparisons in clinical trials, we performed this systematic review and network…

DIETA E “HEALTHY AGEING”. UN’ENORME RICERCA SU COMPORTAMENTI DIETETICI ED AMBITI DI VITA IN 105.000 PARTECIPANTI SEGUITI PER 30 ANNI. DA”NATURE MEDICINE” (FREE!)

Optimal dietary patterns for healthy aging Anne-Julie Tessier et al. Abstract As the global population ages, it is critical to identify diets that, beyond preventing noncommunicable diseases, optimally promote healthy aging. Here, using longitudinal questionnaire data from the Nurses’ Health Study (1986–2016) and the Health Professionals Follow-Up Study (1986–2016), we examined the association of long-term…

BREAKING NEWS! L’APPENDICECTOMIA RIDUCE IL RISCHIO DI RECIDIVA NELLA COLITE ULCEROSA! DA”THE LANCET GASTROENTEROLOGY & HEPATOLOGY” (FREE!)

Appendicectomy plus standard medical therapy versus standard medical therapy alone for maintenance of remission in ulcerative colitis (ACCURE): a pragmatic, open-label, international, randomised trial The ACCURE Study Group Summary Background The appendix might have an immunomodulatory role in ulcerative colitis. Appendicectomy has been suggested as a potentially therapeutic intervention to maintain remission in ulcerative colitis.…