EMORRAGIA DIGESTIVA SUPERIORE. QUALE SCORE E’ PIU’ VALIDO? UN CONFRONTO TRA I DIVERSI TOOL. NON MALE ANCHE IL GLORIOSO PNED SCORE ITALIANO! VERSO UN NUOVO SCORE? DA “DIGESTIVE AND LIVER DISEASE”

Comparison of assessment tools in acute upper gastrointestinal bleeding: Which one at which time point? Riccardo Marmo et al. Abstract Background Decisions on managing bleeders remain a critical issue due to the high death risk. The Glasgow-Blatchford score (GBS) correctly identifies low-risk patients but none of the existing scores precisely assess the high risk patients.…

DIPENDENZA DA ALCOL. LE NUOVE (OTTIME) LINEE GUIDA DAL CANADA (FREE).

Canada’s Guidance on Alcohol and Health: Final Report This document was published by the Canadian Centre on Substance Use and Addiction (CCSA). Paradis, C. et al. About this Document This report contains three documents produced for three different target groups. Public Summary The Public Summary is a one-page summary intended for the general public. Technical…

IL MICROBIOTA RESPONSABILE DEL FALLIMENTO DELLA TERAPIA CON 5-ASA NELLE IBD? OCCHIO AL REPORT DA “IBD” (FREE)

GUT MICROBIAL METABOLISM OF 5-ASA IS PROSPECTIVELY ASSOCIATED WITH TREATMENT FAILURE IN PATIENTS WITH IBD  Raaj Mehta et al. Abstract BACKGROUND Variation in clinical response to 5-aminosalicylic acid (5-ASA) has been attributed in part to its inactivation by gut microbes. Recently, in the Inflammatory Bowel Disease (IBD) Multi’omics Database (IBDMDB), a multicenter year-long cohort of…

STATE PENSANDO DI PARTIRE CON UN TRIAL IN CHIRURGIA? OTTIMO! MA PRIMA LEGGETE QUI! DA “JAMA SURGERY”.

Practical Guide to Designing a Clinical Trial in Surgery Panos Kougias et al A randomized clinical trial represents a controlled experiment in which the investigator applies an intervention to a group of patients and subsequently observes its effect on 1 or more outcomes over time. In this article, we outline the key elements that need…

MICROBIOTA E CHEMIOTERAPIA: EFFICACIA O TOSSICITA’ ? UNA SPLENDIDA REVIEW DALL’IMPERIAL COLLEGE DI LONDRA. DA “GASTROENTEROLOGY” (FREE).

Gut Microbiota Modulation of Efficacy and Toxicity of Cancer Chemotherapy and Immunotherapy Despoina Chrysostomou et al. Accumulating evidence supports not only the functional role of the gut microbiome in cancer development and progression but also its role in defining the efficacy and toxicity of chemotherapeutic agents (5-fluorouracil, cyclophosphamide, irinotecan, oxaliplatin, gemcitabine, methotrexate) and immunotherapeutic compounds…

LINEE GUIDA PER LA MALATTIA CELIACA 2023. DA “AMERICAN JOURNAL OF GASTROENTEROLOGY” (FREE).

American College of Gastroenterology Guidelines Update: Diagnosis and Management of Celiac Disease Rubio-Tapia, Alberto et al. Abstract This guideline presents an update to the 2013 American College of Gastroenterology Guideline on the Diagnosis and Management of Celiac Disease with updated recommendations for the evaluation and management of patients with celiac disease (CD). CD is defined…