The UpPriority tool supported prioritization processes for updating clinical guideline questions Andrea Juliana Sanabria et al. Abstract Objective: We aim to 1) use the UpPriority tool to identify which clinical questions (CQs) within the clinical guidelines (CGs) need to be prioritized for updating and 2) assess the implementation of the tool in a real-world set of…
Moving Beyond Guidelines—Use of Value-Based Preoperative Testing Niloofar Latifi, et al. In 2010, the Institute of Medicine estimated that the annual waste in health care spending is $750 billion, with $210 billion associated with providing unnecessary services.1 Routine preoperative testing in low-risk patients has long been identified as low-value care. In this issue of JAMA Internal Medicine, Shenoy…
African languages to get more bespoke scientific terms Many words common to science have never been written in African languages. Now, researchers from across Africa are changing that. There’s no original isiZulu word for dinosaur. Germs are called amagciwane, but there are no separate words for viruses or bacteria. A quark is ikhwakhi (pronounced kwa-ki); there is no…
A Famous Honesty Researcher Is Retracting A Study Over Fake Data Renowned psychologist Dan Ariely literally wrote the book on dishonesty. Now some are questioning whether the scientist himself is being dishonest. A landmark study that endorsed a simple way to curb cheating is going to be retracted nearly a decade later after a group of…
Systematic review and network meta-analysis: efficacy of licensed drugs for abdominal bloating in irritable bowel syndrome with constipation Alfred D. Nelson et al. Summary Background Although bloating is a highly prevalent and troublesome symptom in irritable bowel syndrome with constipation (IBS-C), treatment is empirical with no specific guidelines for its management. Aim To conduct a…
Effect of Oral Ranitidine on Urinary Excretion of N-Nitrosodimethylamine (NDMA) A Randomized Clinical Trial Jeffry Florian et al. IMPORTANCE In 2019, the US Food and Drug Administration (FDA) received a citizen petition indicating that ranitidine contained the probable human carcinogen N-nitrosodimethylamine (NDMA). In addition, the petitioner proposed that ranitidine could convert to NDMA in humans;…