IBS E DISPEPSIA FUNZIONALE: OCCHIO AI FARMACI NEUROMODULATORI. AUMENTANO IL RISCHIO DI EFFETTI COLLATERALI (IL NOCEBO EFFECT)? UNA META-ANALISI DALL'”AMERICAN JOURNAL OF GASTROENTEROLOGY”.

Examining the Nocebo Effect in Trials of Neuromodulators for Use in Disorders of Gut-Brain Interaction Jeremy R. Glissen Brown et al. INTRODUCTION: Nocebo effects are believed to influence the rate of reported adverse events (AE) and subject withdrawal in both the treatment and placebo groups of randomized clinical trials (RCT). Neuromodulators are commonly prescribed to…

IL CASO ADUCANUMAB PER L’ALZHEIMER. NON CI INTERESSA? E NO! RAPPORTI ANOMALI TRA AGENZIA REGOLATORIA E PRODUTTORE. ATTENZIONE ALLE MODIFICHE PROPOSTE ALLA NOSTRA AIFA. DA “WIRED” (FREE)

Tutti i problemi del primo farmaco anti-Alzheimer Aducanumab ha un prezzo eccessivo, tempi di approvazione inusuali e rapporti anomali tra agenzia regolatoria e produttore SIMONE VALESINI Un ricercatore TEK IMAGE/SCIENCE PHOTO LIBRARY Per anni, l’anticorpo monoclonale Aducanumab è sembrato un farmaco destinato a fare la storia. Sul piano medico – doveva essere la prima terapia in grado…

INTERNET STA FALLENDO ? UNA RIFLESSIONE DI UMAIR HAQUE PER IL 2023. DA “Eudaimonia and Co” (FREE). LEGGETE GENTE, LEGGETE!

2023 Should Be the Year We Admit the Internet Is a Failure With Hate, Rage, Bigotry, and Ignorance, the Internet’s Destroying Our Ability to Be a Civilization — When We Need it Most umair haque Image Credit: 1, 2 It’s 2023, and there’s something that’s gone badly wrong with human civilization. No, I don’t just mean the…

SOTORASIB PER IL CANCRO PANCREATICO AVANZATO. OTTIMI RISULTATI SE ESISTE LA MUTAZIONE KRAS p.G12C. DA”NEJM” (FREE).

Sotorasib in KRAS p.G12C–Mutated Advanced Pancreatic Cancer John H. Strickler et al. BACKGROUND KRAS p.G12C mutation occurs in approximately 1 to 2% of pancreatic cancers. The safety and efficacy of sotorasib, a KRAS G12C inhibitor, in previously treated patients with KRAS p.G12C–mutated pancreatic cancer are unknown. METHODS We conducted a single-group, phase 1–2 trial to assess the…

EPATITE CRONICA DA VIRUS B. DUSHEIKO E COLL. SUI NUOVI APPROCCI ! DA “NEJM” (FREE).

New Approaches to Chronic Hepatitis B Geoffrey Dusheiko et al. Chronic hepatitis B is caused by the hepatitis B virus (HBV), a hepatotropic DNA virus that can replicate at high levels and cause minimal disease or severe liver injury. The clinical spectrum of chronic hepatitis B ranges from no symptoms to progressive hepatic fibrosis, advanced…

DVQOL: UN NUOVO PARAMETRO PER MISURARE LA QUALITA’ DI VITA DEL PAZIENTE CON MALATTIA DIVERTICOLARE. DA “ANNALS OF SURGERY” (FREE)

What’s in a Number? Assessing the Burden of Diverticular Disease Mariam N. Hantouli et al. INTRODUCTION Annually, nearly 3 million Americans are diagnosed with diverticulitis, and 1 in 4 have recurrent episodes.1,2 The American Society of Colon and Rectal Surgeons recommends individualizing the decision to operate based on the impact of diverticular disease on quality of…