RNA SEQUENCING: CONE FUNZIONE LA TECNICA DIAGNOSTICA. DA JAMA.

RNA Sequencing as a Diagnostic Tool Shamika Ketkar et al.     RNA sequencing (RNA-seq) is a new tool in the genetic diagnostic laboratory made possible by the advent of low-cost, high-throughput, next-generation sequencing technology. Historically, RNA studies were limited to gene expression using microarray technology for the detection of gene rearrangements and quantification of gene expression for predefined…

CARI GASTROENTEROLOGI ED INTERNISTI, FORSE PER GESTIRE I VOSTRI PAZIENTI E’ MEGLIO RIVEDERE UN PO’ I DISTURBI DI ANSIA . DA JAMA .

Anxiety Disorders: A Review Kristin L. Szuhany; Naomi M. Simon Importance  Anxiety disorders have a lifetime prevalence of approximately 34% in the US, are often chronic, and significantly impair quality of life and functioning. Observations  Anxiety disorders are characterized by symptoms that include worry, social and performance fears, unexpected and/or triggered panic attacks, anticipatory anxiety, and avoidance behaviors.…

IL COSIDDETTO “TARGET TRIAL”: DAI DATI OSSERVAZIONALI AL TRIAL SIMULATO. UDITE, UDITE! E RISPARMIATE ! DAL “BMJ” (FREE).

Target trial emulation: applying principles of randomised trials to observational studies Anthony A Matthews et al.   “using observational data to emulate a target trial”   The randomised trial is the preferred study design for evaluating the effectiveness and safety of interventions. Yet such trials can be prohibitively expensive, unethical, or take too long. When…

LE 10 PUBBLICAZIONI PIU’ IMPORTANTI IN GASTROENTEROLOGIA DEL 2022, SECONDO MEDSCAPE E DAVID JOHNSON (FREE).

2022’s Top 10 Gastroenterology Publications David A. Johnson, MD ‘Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis’ The WATERFALL study was an early weight-based comparison of aggressive vs nonaggressive goal-directed fluid resuscitation in the initial phase of acute pancreatitis. Patients were randomly assigned to receive intravenous (IV) fluids (lactated Ringer solution) of either aggressive (IV bolus of 20…

GASTROPARESI: VINCE LA CLEBOPRIDE NETTAMENTE SU DOMPERIDONE. UNA OTTIMA NETWORK META-ANALISI DAL GRUPPO DI CAMILLERI. DA GASTROENTEROLOGY (FREE).

Efficacy and Safety of Drugs for Gastroparesis: Systematic Review and Network Meta-analysis. Maria Rosa Ingross et al. Background & Aims Although there have been multiple drugs tested in gastroparesis, their relative efficacy and safety is unknown. We evaluated this in a network meta-analysis of randomized controlled trials (RCTs). Methods We searched the literature to 7th September…

REVISIONI SISTEMICHE E REPLICABILITA’. ATTENZIONE : REPRODUCIBILITY IS ARRIVING! UNA LETTERA IMPORTANTE DAL “J.OF CLINICAL EPIDEMIOLOGY” (FREE)

Replicability in the context of systematic reviews: A call for a framework with considerations regarding duplication, overlap, and intentionality Livia Puljak, Dawid Pieper Letter to the editor Reproducibility and replicability are considered central to the development and evolution of science, as they should ensure the efficient generation of reliable knowledge [[1. Much has been written…