Finding clues in unexpected places: detection of pancreatic cancer through the faecal microbiome Rachel Newsome AND Christian Jobin Pancreatic cancer is an intractable form of cancer that ranks as the 12th most common cancer worldwide (2.7%) but alarmingly is predicted to increase in the next two decades.1 Pancreatic ductal adenocarcinoma (PDAC) is the most common form…
A faecal microbiota signature with high specificity for pancreatic cancer Ece Karta et al. Abstract Background Recent evidence suggests a role for the microbiome in pancreatic ductal adenocarcinoma (PDAC) aetiology and progression. Objective To explore the faecal and salivary microbiota as potential diagnostic biomarkers. Methods We applied shotgun metagenomic and 16S rRNA amplicon sequencing to samples from…
Efficacy of peroxisome proliferator-activated receptor agonists, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors for treatment of non-alcoholic fatty liver disease: a systematic review Alessandro Mantovani et al. There are no licensed treatments for non-alcoholic fatty liver disease (NAFLD), but three different classes of antihyperglycaemic drugs—peroxisome proliferator-activated receptor (PPAR) agonists, glucagon-like peptide-1 receptor (GLP-1R) agonists,…
Self-expandable metal stents versus endoscopic balloon dilation for the treatment of strictures in Crohn’s disease (ProtDilat study): an open-label, multicentre, randomised trial Carme Loras et al. Background Endoscopic balloon dilation (EBD) is the established endoscopic treatment for short strictures in Crohn’s disease. Fully covered self-expandable metal stents (FCSEMS) have been used for endoscopic treatment…
Understanding and Communicating Uncertainty in Achieving Diagnostic Excellence Maria R. Dahm, MA, PhD1; Carmel Crock, MBBS, BLit Uncertainty pervades the diagnostic process. In health care, taxonomies of uncertainty have been developed to describe aspects such as personal (eg, individual knowledge gaps), scientific (eg, limits of biomedical knowledge), and probabilistic (eg, imprecise estimates of risk or prognosis) dimensions of uncertainty.1 …
Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline Pierre H Deprez et al. 1: ESGE recommends endoscopic ultrasonography (EUS) as the best tool to characterize subepithelial lesion (SEL) features (size, location, originating layer, echogenicity, shape), but EUS alone is not able to distinguish among all types of SEL.Strong…