UPADACITINIB E’ EFFICACE NEL CROHN PERIANALE CON FISTOLA: UN ANALISI POST-HOC DI 3 TRIAL. RISOLUZIONE DEL DRENAGGIO +47% A 12 SETTIMANE. DA ” Clinical Gastroenterology and Hepatology” (FREE)

CHIRURGIA, GASTROENTEROLOGIA, IBD, METODOLOGIA, Senza categoria

Efficacy and Safety of Upadacitinib for Perianal Fistulizing Crohn’s Disease: A Post Hoc Analysis of 3 Phase 3 Trials Jean-Frédéric Colombel et al. ABSTRACT BACKGROUND & AIMS Efficacy of upadacitinib, an oral Janus kinase inhibitor, for moderate-to-severe Crohn’s disease was demonstrated in phase 3 induction (U-EXCEL, U-EXCEED) and maintenance (U-ENDURE) trials; this post hoc analysis evaluated…

IL TASSO DI RISPOSTA AL PLACEBO NEI TRIAL SULLA MALATTIA DI CROHN. UN’ ATTENTA META-ANALISI SU DATI INDIVIDUALI. NELLA INDUZIONE LA INCIDENZA E’ DEL 27%. ANALISI DEI FATTORI DI RISPOSTA. DA”GASTROENTEROLOGY”

CHIRURGIA, GASTROENTEROLOGIA, IBD, METODOLOGIA, Senza categoria

Placebo rates in Crohn’s disease randomized clinical trials: An individual patient data meta-analysis Virginia Solitano et al. ABSTRACT (260/260) Background & Aims Understanding placebo rates is critical for efficient clinical trial design. We assessed placebo rates and associated factors using individual patient data (IPD) from Crohn’s disease (CD) trials. Methods We conducted a meta-analysis of…

MALNUTRIZIONE DELL’ADULTO. UNA MAGNIFICA REVIEW DA “NEJM”

GASTROENTEROLOGIA, MEDICI DI FAMIGLIA, MEDICINA INTERNA, NEWSLETTER, NUTRIZIONE

Malnutrition in Adults Tommy Cederholm, M.D., Ph.D., and Ingvar Bosaeus, M.D., Ph.D. Malnutrition is an imbalance between the growth and breakdown of body tissues and nutrient stores, resulting in loss of muscle and organ mass, diminished physical and mental functioning, and impaired clinical outcomes. Over the past 50 years, malnutrition has been increasingly recognized as…

ATTENZIONE, O CHIRURGHI! LA TERAPIA PER L’ADENOCARCINOMA DELLA GIUNZIONE ESOFAGO-GASTRICA VA VERSO UN’ IMPORTANTE PERSONALIZZAZIONE ! DA “THE LANCET ONCOLOGY”

CHIRURGIA, ENDOSCOPIA, GASTROENTEROLOGIA, NEWSLETTER, ONCOLOGIA

Improving individualised therapies in localised gastro-oesophageal adenocarcinoma Magali Svrcek et al. Summary Despite our increased understanding of the biological and molecular aspects of gastro-oesophageal tumourigenesis, the identification of prognostic or predictive factors remains challenging. Patients with resectable gastric and oesophageal adenocarcinoma are often treated similarly after surgical resection, regardless of their tumour biology, clinical characteristics,…

LE ULTIME TERAPIE PER LE IBD. CONSIDERAZIONI PRATICHE E POSIZIONAMENTO. DA ” GASTROENTEROLOGY “

GASTROENTEROLOGIA, IBD, NEWSLETTER, Senza categoria

Modern Advanced Therapies for Inflammatory Bowel Diseases: Practical Considerations and Positioning David Fudma et al. Abstract The therapeutic armamentarium for management of inflammatory bowel diseases has expanded dramatically in the last 5 years, with the introduction of several medications with different mechanisms of action. These include the oral small molecule drugs Janus kinase inhibitors (including upadacitinib…

PANCREATITE CRONICA. QUALE RUOLO PER L’ENDOSCOPIA? LE NUOVE LINEE GUIDA DELLA AMERICAN SOCIETY FOR GASTROINTESTINAL ENDOSCOPY. DA “Gastrointest Endosc”.

CHIRURGIA, ECOGRAFIA ED ECOENDOSCOPIA, ENDOSCOPIA, GASTROENTEROLOGIA, NEWSLETTER, PANCREAS E VIE BILIARI, Senza categoria

American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in the management of chronic pancreatitis: summary and recommendations Prepared by: THE ASGE STANDARDS OF PRACTICE COMMITTEE This clinical practice guideline from the American Society for Gastrointestinal Endoscopy (ASGE) provides an evidence-based approach for the role of endoscopy in the management of chronic pancreatitis…