Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review Angelo Del Gaudio et al Abstract Acute pancreatitis (AP) is an acute inflammation of the pancreas caused by the activation of digestive enzymes in the pancreatic tissue. The main causes of AP are cholelithiasis and alcohol abuse; less commonly, it can…
Replication games: how to make reproducibility research more systematic Abel Brodeur, Anna Dreber, Fernando Hoces de la Guardia & Edward Miguel In some areas of social science, around half of studies can’t be replicated. A new test-fast, fail-fast initiative aims to show what research is hot — and what’s not. In October last year, one of…
Hepatitis C Marianne Martinello, PhD et al. Summary Hepatitis C virus (HCV) is a hepatotropic RNA virus that can cause acute and chronic hepatitis, with progressive liver damage resulting in cirrhosis, decompensated liver disease, and hepatocellular carcinoma. In 2016, WHO called for the elimination of HCV infection as a public health threat by 2030. Despite…
Ulcerative Colitis in Adults A Review Beatriz Gros, MD; Gilaad G. Kaplan, MD, MPH This review focuses on the epidemiology, pathophysiology, diagnosis, and treatment of UC. IMPORTANCE Ulcerative colitis (UC) is a chronic inflammatory condition of the colon, with a prevalence exceeding 400 per 100 000 in North America. Individuals with UC have a lower…
Poliprotect vs Omeprazole in the Relief of Heartburn, Epigastric Pain, and Burning in Patients Without Erosive Esophagitis and Gastroduodenal Lesions: A Randomized, Controlled Trial Corazziari, Enrico Stefano MD; Gasbarrini, Antonio MD et al Abstract INTRODUCTION: In the treatment of upper GI endoscopy-negative patients with heartburn and epigastric pain or burning, antacids, antireflux agents, and mucosal…
Early Ileocecal Resection for Crohn’s Disease Is Associated With Improved Long-term Outcomes Compared With Anti-Tumor Necrosis Factor Therapy: A Population-Based Cohort Study Manasi Agrawal et al. Background & Aims Early Crohn’s disease (CD) treatment involves anti-tumor necrosis factor (TNF) agents, whereas ileocecal resection (ICR) is reserved for complicated CD or treatment failure. We compared long-term…