A tale of two antiviral targets — and the COVID-19 drugs that bind them The FDA is considering authorizations for Pfizer’s paxlovid and Merck & Co.’s molnupiravir, the first two oral COVID-19 antivirals. Megan Cully COVID-19, for all of the problems it has created, has shown the unprecedented speed with which drug developers can move.…
Reproducibility in Cancer Biology: Challenges for assessing replicability in preclinical cancer biology Timothy M Errington et al. Abstract We conducted the Reproducibility Project: Cancer Biology to investigate the replicability of preclinical research in cancer biology. The initial aim of the project was to repeat 193 experiments from 53 high-impact papers, using an approach in which the experimental…
Systematic review and meta-analysis of observational studies on BD-IPMNS progression to malignancy lA.Balduzzi et al. Abstract Background The vast majority of presumed branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) of the pancreas are referred to a surveillance program due to the relatively low risk of malignancy. We aim to evaluate all available data from observational studies…
Reproducibility: expect less of the scientific paper Olavo B. Amaral & Kleber Neve Make science more reliable by placing the burden of replicability on the community, not on individual laboratories. In 2018, we embarked on a journey to assess the reproducibility of biomedical research papers from Brazil. Thus began a multicentre collaboration of more than 60…
International Liver Cancer Association (ILCA) White Paper on Biomarker Development for Hepatocellular Carcinoma Amit G. Singal et al. Biomarkers are key components of the clinical management of patients with cancer, as they have contributed to major survival improvements in these patients.1 According to the National Cancer Institute, a biomarker is a biological molecule found in…
IMMEDIATE VERSUS POSTPONED INTERVENTION FOR INFECTED NECROTIZING PANCREATITIS Lotte Boxhoorn et al. Abstract Background: Infected necrotizing pancreatitis is a potentially lethal disease that is treated with the use of a step-up approach, with catheter drainage often delayed until the infected necrosis is encapsulated. Whether outcomes could be improved by earlier catheter drainage is unknown. Methods: We conducted…