DRENAGGIO PER LA PANCREATITE NECROTIZZANTE INFETTA: COME E’ DURA L’ATTESA. L’EDITORIALE DEL NEW ENGLAND OF MEDICINE

CHIRURGIA, GASTROENTEROLOGIA, PANCREAS E VIE BILIARILascia un commento

Drainage for Infected Pancreatic Necrosis — Is the Waiting the Hardest Part? Todd H. Baron, M.D. Acute necrotizing pancreatitis, which occurs in up to 30% of episodes of acute pancreatitis, can be a devastating, life-threatening disease. For many years, acute necrotizing pancreatitis (the cause of clinically severe pancreatitis) was managed with open surgical necrosectomy. Surgeons…

ADDIO H-INDEX ? NON RAPPRESENTA PIU’ LA REPUTAZIONE SCIENTIFICA ! (FREE)

INTERNATIONAL SNAPSHOTS, METODOLOGIA, REAL WORLD EVIDENCELascia un commento

The h-index is no longer an effective correlate of scientific reputation Vladlen Koltun*, David Hafner Abstract The impact of individual scientists is commonly quantified using citation-based measures. The most common such measure is the h-index. A scientist’s h-index affects hiring, promotion, and funding decisions, and thus shapes the progress of science. Here we report a…

BREAKING NEWS: MARCATORI SIERICI PRECLINICI DELLA COLITE ULCEROSA

GASTROENTEROLOGIA, IBD, INTERNATIONAL SNAPSHOTSLascia un commento

Systemic Inflammation in Preclinical Ulcerative Colitis Daniel Bergemalm et al. BACKGROUND & AIMS: Preclinical ulcerative colitis is poorly defined. We aimed to characterize the preclinical systemic inflammation in ulcerative colitis, using a comprehensive set of proteins. METHODS: We obtained plasma samples biobanked from individuals who developed ulcerative colitis later in life (n ¼ 72) and…

BIOPSIA EPATICA OGGI: UNO STUDIO DI REAL WORLD EVIDENCE

EPATOLOGIA, REAL WORLD EVIDENCE, Senza categoriaLascia un commento

Liver biopsy in the real world—reporting, expert concordance and correlation with a pragmatic clinical diagnosis Hannah P. Kim et al. Summary Background: Patients with non-alcoholic steatohepatitis (NASH) and fibrosis stage ≥2 comprise a target population for pharmacotherapy. Liver biopsy, the reference standard for identifying this population, requires complete and accurate assessment of steatohepatitis and fibrosis.…

COME FUNZIONANO I VACCINI ANTI COVID-19: UNA GRANDE ARTICOLO DA NATURE

COVID19 - EVIDENCE, MEDICI DI FAMIGLIA, MEDICINA INTERNALascia un commento

How protein-based COVID vaccines could change the pandemic Jabs from Novavax and other biotech firms are coming. Scientists say they have a lot to offer. Elie Dolgin Pamela Sherry is eager to become immunized against COVID-19. But she has put off getting a jab. “I believe vaccines work,” she says. “I want the protection.” Yet…

COME INTERPRETARE L’HAZARD RATIO : UN’OTTIMA SPIEGAZIONE PER SPIEGARE RISCHI E VANTAGGI

METODOLOGIA, REAL WORLD EVIDENCE, Senza categoriaLascia un commento

Come interpretare nella pratica il valore dell’ Hazard Ratio? gianfranco L’Hazard ratio (HR) è una delle misure che nella ricerca clinica spesso sono più difficili da interpretare per studenti e ricercatori. Ogni volta che mi capita di assistere un non-statistico che ha un’analisi di sopravvivenza da gestire o un paper da scrivere, al citare dell’HR…