BREAKING NEWS ! REGRESSIONE TOTALE DEL CANCRO DEL RETTO LOCALMENTE AVANZATO CON BLOCCO DELLA PROGRAMMED DEATH (PD-1 ). “FREE” DAL NEJM

PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer Andrea Cercek et al. Abstract BACKGROUND Neoadjuvant chemotherapy and radiation followed by surgical resection of the rectum is a standard treatment for locally advanced rectal cancer. A subset of rectal cancer is caused by a deficiency in mismatch repair. Because mismatch repair–deficient colorectal cancer is responsive…

IL MICROBIOTA E’ ASSOCIATO ALLA RISCHIO DI ICTUS ED ALLA SUA SEVERITA’! UNA OTTIMA SINTESI DA Medscape Gastroenterology DOPO IL CONGRESSO DELLA ESOC (European Stroke Organisation Conference).

Gut Bacteria Linked to Stroke Severity, Risk Kelli Whitlock Burton Two new studies identifying strains of gut microbiota associated with more severe strokes and worse post-stroke recovery point to a possible role for the gut microbiome in preventing stroke and improving outcomes. Researchers identified gut microbiota that were different in stroke patients compared to control…

ERADICAZIONE DI HELICOBACTER PYLORI PER LA DISPEPSIA FUNZIONALE. L’ULTIMA DELLE META-ANALISI: IL GUADAGNO TERAPEUTICO E’ MODESTO. DA GUT.

Efficacy of Helicobacter pylori eradication therapy for functional dyspepsia: updated systematic review and meta-analysis Alexander C Ford et al. Abstract Objective Functional dyspepsia (FD) is a chronic disorder that is difficult to treat. Helicobacter pylori may contribute to its pathophysiology. A Cochrane review from 2006 suggested that eradication therapy was beneficial, but there have been numerous randomised controlled trials (RCTs)…

SUL CONFLITTO DI INTERESSI: UNA NUOVA FORTE POLEMICA CON IL NEJM & CO. DA STAT+

NEJM, other journals: provide more transparency about conflicts of interest or don’t publish conflicted articles Martin F. Shapiro and Sidney M. Wolfe Are medical journals reliable sources of objective information, or do they, at times, act as shills for the pharmaceutical industry and other interests? We believe the latter after reading a Perspective article on drug pricing…

EBM 2022 E SLOW MEDICINE. UNA OTTIMA RIFLESSIONE CON MARCO BOBBIO, MICHELA CHIARIO E PAOLA ARCADI

Per Slow Medicine le prove sono indispensabili Tre esponenti del movimento per una medicina sobria, rispettosa e giusta intervengono nel dialogo sull’attualità dell’ebm La filosofia del movimento Slow Medicine [1] considera indispensabile basare la pratica medica sulle prove scientifiche, ma richiama l’attenzione dei professionisti sanitari a una lettura critica della letteratura e delle linee guida…

CANCRO DEL PANCREAS ED IMAGING: E’ TEMPO DI STANDARDIZZARE I REFERTI DI TAC E RISONANZA? DA “CLINICAL GASTROENTEROLOGY AND HEPATOLOGY”

Association of standardized radiology reporting and management of abdominal CT and MRI with diagnosis of pancreatic cancer Eleanor L Ormsby et al. Abstract Background & aims: Follow-up of abdominal computed tomography (CT) and magnetic resonance imaging (MRI) findings suspicious for pancreatic cancer may be delayed if documentation is unclear. We evaluated whether standardized reporting and follow-up…