How to Interpret and Use a Clinical Practice Guideline or RecommendationUsers’ Guides to the Medical Literature Romina Brignardello-Petersen,et al. Abstract Importance Clinicians may rely on recommendations from clinical practice guidelines for management of patients. Observations A clinical practice guideline is a published statement that includes recommendations that are intended to optimize patient care. In the guideline development process,…
ACG Clinical Guidelines: Management of Benign Anorectal Disorders Arnold Wald et al Abstract Benign anorectal disorders of structure and function are common in clinical practice. These guidelines summarize the preferred approach to the evaluation and management of defecation disorders, proctalgia syndromes, hemorrhoids, anal fissures, and fecal incontinence in adults and represent the official practice recommendations…
JBIMANUAL FOR EVIDENCE SYNTHESIS April 2021 JBI Manual for Evidence Synthesis Welcome to the JBI Manual for Evidence Synthesis JBI is an international evidence-based healthcare research organisation that works with 70+ Universities and Hospitals (known as the JBI Collaboration) around the world. The organisation focuses on improving health outcomes globally by producing and disseminating research…
TVB-2640 (FASN Inhibitor) for the Treatment of Nonalcoholic Steatohepatitis: FASCINATE-1, a Randomized, Placebo-Controlled Phase 2a Trial Rohit Loomba et al. Background & Aims Increased de novo lipogenesis creates excess intrahepatic fat and lipotoxins, propagating liver damage in nonalcoholic steatohepatitis. TVB-2640, a fatty acid synthase inhibitor, was designed to reduce excess liver fat and directly inhibit…
Predictors of Opioid Prescribing for Non-Malignant Low Back Pain in an Italian Primary Care Setting Simona Cammarota et al. This study explores which patient characteristics could affect the likelihood of starting low back pain (LBP) treatment with opioid analgesics vs. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in an Italian primary care setting. Through the computerized medical records…
Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease Fasiha Kanwal et al. Find AGA’s NASH Clinical Care Pathway App for iOS and Android mobile devices at nash.gastro.org. Scan this QR code to be taken directly to the website.Nonalcoholic fatty liver disease (NAFLD) is becoming increasingly common, currently affecting…