The promise of the gut microbiome as part of individualized treatment strategies Daniel A. Schupack, et al. Abstract Variability in disease presentation, progression and treatment response has been a central challenge in medicine. Although variability in host factors and genetics are important, it has become evident that the gut microbiome, with its vast genetic and…
Understanding one in 100,000 What does this tiny probability look like? Anthony B. Masters The EMA stated there was a plausible link between the Oxford-AstraZeneca (Vaxzevria) vaccine and rare blood clots. The European Medicines Agency said the probability of this kind of blood clot was “very low”. With millions vaccinated, very rare side effects can emerge. The Paul-Ehrlich-Institut reported…
Update on the management of sigmoid diverticulitis Mark H Hanna, Andreas M Kaiser Abstract Diverticular disease and diverticulitis are the most common non-cancerous pathology of the colon. It has traditionally been considered a disease of the elderly and associated with cultural and dietary habits. There has been a growing evolution in our understanding and the…
Is Ivermectin For Covid-19 Based On Fraudulent Research? Part 4 The story of ivermectin for Covid-19 continues to get even more worrisome Gideon M-K; Health Nerd This is part 4 in what appears to be a deep well of research issues underpinning the entire evidence-base for ivermectin and Covid-19. Part 1 is here. Part 2 is here. Part…
Key concepts in clinical epidemiology: Stepped wedge trials Richard Hooper Abstract A stepped wedge trial evaluates an intervention that is implemented over a number of time periods according to a staggered timetable. Stepped wedge trials are usually cluster randomized, the intervention being delivered at some geographical, service or other cluster level. There is considerable variety…
AGA Clinical Practice Update on Endoscopic Surveillance and Management of Colorectal Dysplasia in Inflammatory Bowel Diseases: Expert Review Sanjay K. Murthy et al. Improvements in disease management, as well as endoscopic technology and quality, have dramatically changed the way in which we conceptualize and manage inflammatory bowel disease–related dysplasia over the past 20 years. Based…