DIAGNOSI PRECOCE DEL CANCRO DEL PANCREAS: UN MARCATORE FECALE AD ALTA SPECIFICITA’ : AUROC 0.94. DA “GUT” (FREE)

A faecal microbiota signature with high specificity for pancreatic cancer   Ece Karta et al. Abstract Background Recent evidence suggests a role for the microbiome in pancreatic ductal adenocarcinoma (PDAC) aetiology and progression. Objective To explore the faecal and salivary microbiota as potential diagnostic biomarkers. Methods We applied shotgun metagenomic and 16S rRNA amplicon sequencing to samples from…

NASH: UNA REVISIONE SISTEMATICA SULLE ULTIME TERAPIE. DA “LANCET” : PRIMO NOME ALBERTO MANTOVANI (VERONA)

Efficacy of peroxisome proliferator-activated receptor agonists, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors for treatment of non-alcoholic fatty liver disease: a systematic review Alessandro Mantovani  et al. There are no licensed treatments for non-alcoholic fatty liver disease (NAFLD), but three different classes of antihyperglycaemic drugs—peroxisome proliferator-activated receptor (PPAR) agonists, glucagon-like peptide-1 receptor (GLP-1R) agonists,…

MORBO DI CROHN: PER LE STENOSI MEGLIO LA DILATAZIONE CON PALLONE O L’INSERIMENTO DI PROTESI? UN OTTIMO TRIAL.

Self-expandable metal stents versus endoscopic balloon dilation for the treatment of strictures in Crohn’s disease (ProtDilat study): an open-label, multicentre, randomised trial Carme Loras et al.   Background Endoscopic balloon dilation (EBD) is the established endoscopic treatment for short strictures in Crohn’s disease. Fully covered self-expandable metal stents (FCSEMS) have been used for endoscopic treatment…

COME COMUNICARE IL RISULTATO DI UN TEST DI DIAGNOSI AL PAZIENTE. E COME COMUNICARE L’INCERTEZZA DEL RISULTATO! DA “JAMA” (FREE)

Understanding and Communicating Uncertainty in Achieving Diagnostic Excellence Maria R. Dahm, MA, PhD1; Carmel Crock, MBBS, BLit Uncertainty pervades the diagnostic process. In health care, taxonomies of uncertainty have been developed to describe aspects such as personal (eg, individual knowledge gaps), scientific (eg, limits of biomedical knowledge), and probabilistic (eg, imprecise estimates of risk or prognosis) dimensions of uncertainty.1  …

LINEA GUIDA ESGE PER LA GESTIONE ENDOSCOPICA DELLE LESIONI SUBEPITELIALI: UN OTTIMO AVANZAMENTO (FREE).

Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline Pierre H Deprez et al. 1: ESGE recommends endoscopic ultrasonography (EUS) as the best tool to characterize subepithelial lesion (SEL) features (size, location, originating layer, echogenicity, shape), but EUS alone is not able to distinguish among all types of SEL.Strong…

TERAPIA SISTEMICA CON ANTIBIOTICI. LA VANCOMICINA PREVIENE L’INFEZIONE DA CLOSTRIDIODES DIFFICILE. UNA OTTIMA META-ANALISI ITALIANA CON “TRIAL SEQUENTIAL ANALYSIS” (FREE)

Oral Vancomycin Prophylaxis for Primary and Secondary Prevention of Clostridioides difficile Infection in Patients Treated with Systemic Antibiotic Therapy: A Systematic Review, Meta-Analysis and Trial Sequential Analysis Alberto Enrico Maraolo et al. Abstract Background: Clostridioides difficile infection (CDI) is associated with substantial morbidity and mortality as well as high propensity of recurrence. Systemic antibiotic therapy (SAT) represents the top…