MARCATORI PER IL CARCINOMA EPATOCELLULARE: IL “WHITE PAPER” DALLA INTERNATIONAL LIVER CANCER ASSOCIATION

International Liver Cancer Association (ILCA) White Paper on Biomarker Development for Hepatocellular Carcinoma Amit G. Singal et al. Biomarkers are key components of the clinical management of patients with cancer, as they have contributed to major survival improvements in these patients.1 According to the National Cancer Institute, a biomarker is a biological molecule found in…

PANCREATITE NECROTIZZANTE INFETTA : IL DRENAGGIO PRECOCE NON SEMBRA SUPERIORE AL TARDIVO. UN GRANDE TRIAL MULTICENTRICO DAL NEJM

IMMEDIATE VERSUS POSTPONED INTERVENTION FOR INFECTED NECROTIZING PANCREATITIS Lotte Boxhoorn et al. Abstract Background: Infected necrotizing pancreatitis is a potentially lethal disease that is treated with the use of a step-up approach, with catheter drainage often delayed until the infected necrosis is encapsulated. Whether outcomes could be improved by earlier catheter drainage is unknown. Methods: We conducted…

DRENAGGIO PER LA PANCREATITE NECROTIZZANTE INFETTA: COME E’ DURA L’ATTESA. L’EDITORIALE DEL NEW ENGLAND OF MEDICINE

Drainage for Infected Pancreatic Necrosis — Is the Waiting the Hardest Part? Todd H. Baron, M.D. Acute necrotizing pancreatitis, which occurs in up to 30% of episodes of acute pancreatitis, can be a devastating, life-threatening disease. For many years, acute necrotizing pancreatitis (the cause of clinically severe pancreatitis) was managed with open surgical necrosectomy. Surgeons…

ADDIO H-INDEX ? NON RAPPRESENTA PIU’ LA REPUTAZIONE SCIENTIFICA ! (FREE)

The h-index is no longer an effective correlate of scientific reputation Vladlen Koltun*, David Hafner Abstract The impact of individual scientists is commonly quantified using citation-based measures. The most common such measure is the h-index. A scientist’s h-index affects hiring, promotion, and funding decisions, and thus shapes the progress of science. Here we report a…

BREAKING NEWS: MARCATORI SIERICI PRECLINICI DELLA COLITE ULCEROSA

Systemic Inflammation in Preclinical Ulcerative Colitis Daniel Bergemalm et al. BACKGROUND & AIMS: Preclinical ulcerative colitis is poorly defined. We aimed to characterize the preclinical systemic inflammation in ulcerative colitis, using a comprehensive set of proteins. METHODS: We obtained plasma samples biobanked from individuals who developed ulcerative colitis later in life (n ¼ 72) and…

BIOPSIA EPATICA OGGI: UNO STUDIO DI REAL WORLD EVIDENCE

Liver biopsy in the real world—reporting, expert concordance and correlation with a pragmatic clinical diagnosis Hannah P. Kim et al. Summary Background: Patients with non-alcoholic steatohepatitis (NASH) and fibrosis stage ≥2 comprise a target population for pharmacotherapy. Liver biopsy, the reference standard for identifying this population, requires complete and accurate assessment of steatohepatitis and fibrosis.…