AGA Clinical Practice Update on Chemoprevention for Colorectal Neoplasia: Expert Review Peter S. Liang et al. DESCRIPTION: The purpose of this expert review is to describe the role of medications for the chemoprevention of colorectal neoplasia. Neoplasia is defined as precancerous lesions (e.g., adenoma and sessile serrated lesion) or cancer. The scope of this review…
ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections Colleen R. Kelly, et al. Clostridioides difficile infection occurs when the bacterium produces toxin that causes diarrhea and inflammation of the colon. These guidelines indicate the preferred approach to the management of adults with C. difficile infection and represent the official practice recommendations of…
The Use of Rifaximin in Patients With Cirrhosis Paolo Caraceni et al. Abstract Rifaximin is an oral nonsystemic antibiotic with minimal gastrointestinal absorption and broad-spectrum antibacterial activity covering both gram-positive and gram-negative organisms. Rifaximin is currently used worldwide in patients with cirrhosis for preventing recurrent HE because its efficacy and safety have been proven by…
The Net Benefit of a treatment should take the correlation between benefits and harms into account Marc Buyse et al. Highlights • The assessment of benefits and harms from experimental treatments often ignores the association between outcomes • The method of generalized pairwise comparisons (GPC) takes into account the association between endpoints • A Net…
Next-Generation Probiotics and Their Metabolites in COVID-19 Thomas Gautier et al. Abstract: Since December 2019, a global pandemic has been observed, caused by the emergence of a new coronavirus, SARS CoV-2. The latter is responsible for the respiratory disease, COVID-19. The infection is also characterized by renal, hepatic, and gastrointestinal dysfunctions suggesting the spread of…
Widely Covered Paper on Ranitidine-Cancer Link Retracted Retraction Watch Staff A paper linking the use of a wildly popular drug for heartburn to cancer has been retracted after the authors concluded that their widely touted finding appears to have resulted from a hiccup in the way they conducted their testing. The 2016 article, in Carcinogenesis, has…