The human gut microbiome and health inequities Katherine R. Amatoa et al. Individuals who are minoritized as a result of race, sexual identity, gender, or socioeconomic status experience a higher prevalence of many diseases. Understanding the biological processes that cause and maintain these socially driven health inequities is essential for addressing them. The gut microbiome…
Simple Blood Test to Detect Colorectal Cancer Roxanne Nelson, RN, BSN In the future, a simple blood test could be added to the options for colorectal screening and could appeal to the people currently put off by the unpleasant necessities such as collecting a fecal sample, or the bowel prep before an invasive colonoscopy. The…
Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia Patrícia O. Guimarães et al. BACKGROUND The efficacy and safety of tofacitinib, a Janus kinase inhibitor, in patients who are hospitalized with coronavirus disease 2019 (Covid-19) pneumonia are unclear. METHODS We randomly assigned, in a 1:1 ratio, hospitalized adults with Covid-19 pneumonia to receive either tofacitinib at a…
Esophageal stenting for benign and malignant disease: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2021 Manon C. W. Spaander et al. Main recommendations Malignant disease 1 ESGE recommends placement of partially or fully covered self-expandable metal stents (SEMSs) for palliation of malignant dysphagia over laser therapy, photodynamic therapy, and esophageal bypass. Strong recommendation, high…
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding Laine, Loren et al. Abstract We performed systematic reviews addressing predefined clinical questions to develop recommendations with the GRADE approach regarding management of patients with overt upper gastrointestinal bleeding. We suggest risk assessment in the emergency department to identify very-low-risk patients (e.g., Glasgow-Blatchford score = 0–1) who…
ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury Chalasani, Naga P. et al. Abstract Idiosyncratic drug-induced liver injury (DILI) is common in gastroenterology and hepatology practices, and it can have multiple presentations, ranging from asymptomatic elevations in liver biochemistries to hepatocellular or cholestatic jaundice, liver failure, or chronic hepatitis. Antimicrobials, herbal and…