NON SPRECATE TEMPO PER LA VOSTRA RICERCA: PRIMA FATE UNA META-ANALISI DEGLI STUDI GIA’ PUBBLICATI! DAL GRUPPO DI IOANNIDIS. “Journal of Clinical Epidemiology”.

METODOLOGIA, NEWSLETTER, REAL WORLD EVIDENCE, Senza categoria

Peer review before trial conduct could increase research value and reduce waste Maximilian Siebert , Florian Naudet , and  John P.A. Ioannidis Highlights ° Traditional peer-review of clinical trials happens after the trials are already done ° In this piece we examine several options for review and improvement of trials before they are conducted ° Innovative ideas are necessary…

UNA GUIDA 2023 PER UNA MIGLIORE REVISIONE SISTEMATICA. MOLTE META-ANALISI SONO POCO INFORMATIVE. IOANNIDIS COLPISCE ANCORA! DA “BMC Infectious Diseases” (FREE).

METODOLOGIA, NEWSLETTER, REAL WORLD EVIDENCE, Senza categoria

Guidance to best tools and practices for systematic reviews Kat Kolaski1, Lynne Romeiser Logan,  and John P. A. Ioannidis Abstract Data continue to accumulate indicating that many systematic reviews are methodologically fawed, biased, redundant, or uninformative. Some improvements have occurred in recent years based on empirical methods research and standardization of appraisal tools; however, many authors do not…

RIFAXIMINA PER LA PREVENZIONE DELLA DIVERTICOLITE. LA EVIDENZA NON E’ ANCORA DEFINITIVA. UNA META-ANALISI DAL CLUB FOR EBG&H. DA “FRONTIERS IN GASTROENTEROLOGY” (FREE)

GASTROENTEROLOGIA, MALATTIA DIVERTICOLARE, MEDICI DI FAMIGLIA, MEDICINA INTERNA, NEWSLETTER

Preventing acute diverticulitis. any roles for non-absorbable antibiotics? in search of evidence: a systematic review, meta-analysis, and trial sequential analysis Maurizio Koch, Alberto Enrico Maraolo, Giuseppe Natoli3 and Salvatore Corrao Background: Hospital admissions for diverticulitis, a complication of diverticular disease, are very much on the increase. Prevention of diverticulitis could cut costs and save lives. Aims: To…

LA INTELLIGENZA ARTIFICIALE GPT-4 IN MEDICINA. BENEFICI E RISCHI. UN GRANDE ARTICOLO DAL “NEJM” CHE MERITA DA SOLO L’ABBONAMENTO

GASTROENTEROLOGIA, INTERNATIONAL SNAPSHOTS, MEDICI DI FAMIGLIA, MEDICINA INTERNA, METODOLOGIA, NEWS DAL MONDO, REAL WORLD EVIDENCE, Senza categoria

Benefits, Limits, and Risks of GPT-4 as an AI Chatbot for Medicine Peter Lee et al. The uses of artificial intelligence (AI) in medicine have been growing in many areas, including in the analysis of medical images,1 the detection of drug interactions,2 the identification of highrisk patients,3 and the coding of medical notes.4 Several such…

MALATTIA DIVERTICOLARE DOPO DIVERTICOLITE. RESEZIONE LAPAROSCOPICA SIGMOIDEA O TERAPIA CONSERVATIVA CON FIBRE (SENZA RIFA). UN OTTIMO TRIAL MULTICENTRICO DALLA FINLANDIA. “JAMA SURGERY” (FREE)

CHIRURGIA, GASTROENTEROLOGIA, MALATTIA DIVERTICOLARE, MEDICINA INTERNA, Senza categoria

Quality-of-Life and Recurrence Outcomes Following Laparoscopic Elective Sigmoid Resection vs Conservative Treatment Following DiverticulitisPrespecified 2-Year Analysis of the LASER Randomized Clinical Trial Alexandre Santos, et al. Key Points Question  Does sigmoid resection improve long-term quality of life of patients with recurring, complicated, or persistent painful diverticulitis compared to conservative treatment? Findings  In this prespecified 2-year follow-up of a randomized…

MICROBIOMA E CANCRO COLORETTALE. VERSO UNA GASTROENTEROLOGIA DI PRECISIONE? UN IMPORTANTE EDITORIALE DA” GASTROENTEROLOGY” (FREE)

CHIRURGIA, GASTROENTEROLOGIA, MEDICINA DEI PROBIOTICI, NEWSLETTER, ONCOLOGIA, Senza categoria

Colorectal Cancer Subtyping With Microbiome—A Game Changer for Personalized Medicine? Chi Chun Wong, Jun Yu Colorectal cancer (CRC) was one of earliest solid tumors to be molecularly characterized, and the cascade of genetic events involved in the initiation and progression of CRC are well established.1 Advances in “omics” platforms encompassing genomic, epigenetic, transcriptomic, and immunologic…