Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome Florence Wong, M.B., B.S., M.D., et al for the CONFIRM Study Investigators* Abstract BACKGROUND The vasoconstrictor terlipressin is used for type 1 hepatorenal syndrome (HRS-1) in many parts of the world and is part of the clinical practice guidelines in Europe. METHODS We conducted…
Type 2 Diabetes Mellitus and COVID-19: A Narrative Review Salvatore Corrao et al. The pandemic of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has involved more than one hundred million individuals, including more than two million deaths. Diabetes represents one of the most prevalent chronic conditions worldwide and significantly increases…
Evidence- based and mechanistic insights into exclusion diets for IBS Paul Moayyedi et al. Abstract Exclusion diets are becoming increasingly popular in the management of irritable bowel syndrome (IBS). Several mechanisms exist by which food items might cause gastrointestinal symptoms, such as direct osmotic effects of food in the gut lumen, changes…
GRADE guidelines 32: GRADE offers guidance on choosing targets of GRADE certainty of evidence ratings Linan Zeng et al. Abstract Objective : To provide practical principles and examples to help GRADE users make optimal choices regarding their ratings of certainty of evidence using a minimally or partially contextualized approach. Study Design and Setting : Based on the…
Pain, placebo, and test of treatment efficacy: a narrative review Lene Vase 1, Karolina Wartolowska 2 Abstract Over the past decade, the mechanisms underlying placebo effects have begun to be identified. At the same time, the placebo response appears to have increased in pharmacological trials and marked placebo effects are found in neurostimulation and surgical trials, thereby posing…
Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19 JACC State-of-the-Art Review Azita H. Talasaz et al. Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). However, the optimal thromboprophylactic regimens remain unknown across the spectrum of illness severity of COVID-19. A variety of antithrombotic agents, doses, and durations of…