MALATTIA DI CROHN. LE LINEE GUIDA DEL GRUPPO IG-IBD APPENA USCITE! DA “Digestive and Liver Disease” (FREE)

Use of biologics for the management of Crohn’s disease: IG-IBD clinical guidelines based on the GRADE methodology FABIO MACALUSO ED Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD) Abstract A cure for Crohn’s disease (CD), a chronic inflammatory disease of the gastrointestinal tract of unknown etiology, is not available, so patients require lifelong…

ONDANSETRON PER IL COLON IRRITABILE – DIARREA: IL TRIAL TRITON + META-ANALISI. BREAKING NEWS DA “ALIMENTARY PHARM & THERAP”

Randomised, Placebo-controlled Trial and Meta-analysis Show Benefit of Ondansetron for Irritable Bowel Syndrome with Diarrhoea: The TRITON Trial Gunn, David et al. Abstract Ondansetron may be beneficial in irritable bowel syndrome with diarrhoea (IBS-D). Aim: To conduct a 12-week parallel group, randomised, double-blind, placebo-controlled trial of ondansetron 4mg o.d. (titrated up to 8mg t.d.s.) in…

ENCEFALOPATIA EPATICA: UNA GRANDE META-ANALISI 2022 DALLA PARTE DEL PAZIENTE! LATTULOSIO O RIFAXIMINA? DA “AMERICAN JOURNAL OF GASTROENTEROLOGY”

Systematic Review and Meta-Analysis on the Effects of Lactulose and Rifaximin on Patient-Reported Outcomes in Hepatic Encephalopathy Andrew M. Moon et al INTRODUCTION: Patients with hepatic encephalopathy (HE) suffer from significant symptoms and impaired quality of life. Improved understanding on the potential benefits of first-line HE therapies may aid patientprovider discussions regarding expected benefits of…

LIVELLI EMATICI DI ENDOTOSSINA: BIOMARCATORI DELLA PROGRESSIONE DELLA NASH. UNA IMPEGNATIVA META-ANALISI DA “CLINICAL GASTROENTEROLOGY & HEPATOLOGY” (FREE).

Blood endotoxin levels as biomarker of non-alcoholic fatty liver disease: a systematic review and meta-analysis Josefin Soppert et al. Abstract Background and Aims: Growing evidence supports a role of gut-derived metabolitesin non-alcoholic fatty liver disease (NAFLD), but the relation of endotoxin levels with gut permeability and NAFLD stage remains unclear. This systematic review with meta-…

E’ UTILE IL NUOVO TRIAL? UN NUOVO TOOL PER EVITARE SPRECHI NELLA RICERCA ! ABBIAMO DA IMPARARE DAI GINECOLOGY! MA IOANNIDIS COLPISCE ANCORA ! DA”BJOG” (FREE).

Assessing the usefulness of randomized trials in obstetrics and gynaecology Janneke van ‘t Hooft et al. Health care professionals will be familiar with how little of what they read in medical journals is of direct value (useful) to their practice.(1) Randomized controlled trials (RCTs) are traditionally at the top of the evidence validity hierarchy for…

ACALASIA : LA MIOTOMIA ENDOSCOPICA PERORALE APPARE SICURA ! UNA OTTIMA REVISIONE SISTEMATICA ITALIANA. DA “ENDOSCOPY”.

Long-term outcomes of peroral endoscopic myotomy for achalasia: a systematic review and meta-analysis Edoardo Vespa et al. Abstract Background The long-term outcomes of esophageal peroral endoscopic myotomy (POEM) are still unknown. Methods We searched electronic databases (MEDLINE/PubMed, EMBASE, Scopus) for studies assessing outcomes after POEM for esophageal achalasia with a minimum median follow-up duration of 36 months.…