Can routine blood tests be modelled to detect advanced liver disease in the community: model derivation and validation using UK primary and secondary care data Theresa Hydes et al. Abstract Objectives Most patients are unaware they have liver cirrhosis until they present with a decompensating event. We therefore aimed to develop and validate an algorithm to…
Development of Severe COVID-19 Adaptive Risk Predictor (SCARP), a Calculator to Predict Severe Disease or Death in Hospitalized Patients With COVID-19 FREE Shannon Wongvibulsin et al. Abstract Background: Predicting the clinical trajectory of individual patients hospitalized with coronavirus disease 2019 (COVID-19) is challenging but necessary to inform clinical care. The majority of COVID-19 prognostic tools…
Massive expansion of human gut bacteriophage diversity Luis F. Camarillo-Guerrer et al. Highlights • Database containing 142,809 non-redundant gut phage genomes from 28,060 metagenomes • Host assignment reveals phage diversity and host range across gut bacteria isolates • Epidemiology analysis unveils 280 viral clusters that are globally distributed • The Gubaphage is a clade that…
Replication of Randomized, Controlled Trials Using Real-World Data: What Could Go Wrong? David Thompson1 Abstract With the growing interest in using real-world evidence (RWE) for regulatory purposes, researchers and policy makers are considering how best to assess the credibility of RWE. Because the randomized controlled trial (RCT) has long been regarded as the gold standard…
Emulating Randomized Clinical Trials With Nonrandomized Real-World Evidence Studies: First Results From the RCT DUPLICATE Initiative Jessica M Franklin et al. Abstract Background: Regulators are evaluating the use of noninterventional real-world evidence (RWE) studies to assess the effectiveness of medical products. The RCT DUPLICATE initiative (Randomized, Controlled Trials Duplicated Using Prospective Longitudinal Insurance Claims: Applying Techniques…
Improving Transparency to Build Trust in Real-World Secondary Data Studies for Hypothesis Testing-Why, What, and How: Recommendations and a Road Map from the Real-World Evidence Transparency Initiative Lucinda S Orsin et al Abstract Real-world data (RWD) and the derivations of these data into real-world evidence (RWE) are rapidly expanding from informing healthcare decisions at the…