Conducting real-world evidence studies on the clinical outcomes of diabetes treatments Sebastian Schneeweiss et al. Abstract Real-world Evidence (RWE), the understanding of treatment effectiveness in clinical practice generated from longitudinal patient-level data from the routine operation of the healthcare system, is thought to complement evidence on the efficacy of medications from RCTs. RWE studies follow…
Direct Oral Anticoagulants Plasma Levels Measurement: Clinical Usefulness from Trials and Real-World Data Francesca Renon 1, et al Abstract Measurement of direct oral anticoagulants (DOACs) activity is not routinely necessary. Indeed, evaluation of DOACs plasmatic concentration is discouraged for the majority of patients, due to the lack of outcome data supporting this approach. Nevertheless, DOAC measurements…
Reporting and methodological quality of COVID-19 systematic reviews needs to be improved: an evidence mapping Yanfei Li et al. Abstract Objectives : To assess the reporting and methodological quality of COVID-19 systematic reviews, and to analyze trends and gaps in the quality, clinical topics, author countries, and populations of the reviews using an evidence mapping…
Acute cough in children and adolescents: A systematic review and a practical algorithm by the Italian Society of Pediatric Allergy and Immunology Gian Luigi Marseglia et al. Abstract The current systematic review presented and discussed the most recent studies on acute cough in pediatric age. After that, the Italian Society of Pediatric Allergy and Immunology…
Current treatment and recent progress in gastric cancer Smita S Joshi, et al. Gastric cancer is not a top-10 malignancy in the United States but represents one of the most common causes of cancer death worldwide. Biological differences between tumors from Eastern and Western countries add to the complexity of identifying standard-of-care therapy based on…
REVIEW ARTICLE Magnetic Resonance Imaging for the diagnosis and management of acute colonic diverticulitis: a review of current and future use Franziska Jerjen et al. Abstract Diverticular disease is one of the most common causes of outpatient visits and hospitalisations across Australia, North America and Europe. According to the Gastroenterological Society of Australia (GESA, 2010),…