LA RIFAXIMINA RIDUCE LA PROGRESSIONE DELLA FIBROSI NELLA MALATTIA EPATICA DA ALCOL ! 1100 MG AL GIORNO PER 18 MESI: RIDUZIONE DEL 20% DI PROGRESSIONE VS PLACEBO odds ratio 0,42 [0·18–0·98]; p=0·044. RCT SU BIOPSIE DA “LANCET” (FREE)

Rifaximin-α for liver fibrosis in patients with alcohol-related liver disease (GALA-RIF): a randomised, double-blind, placebo-controlled, phase 2 trial Mads Israelsen et al. Summary Background Alcohol is the leading cause of liver-related mortality worldwide. The gut–liver axis is considered a key driver in alcohol-related liver disease. Rifaximin-α improves gut-barrier function and reduces systemic inflammation in patients…

L’INSUFFICIENZA RENALE NEL CIRROTICO. L’ULTIMA REVISIONE 2023 DAL GRUPPO DI GARCIA-TSAO. DAL “NEW ENGLAND JOURNAL OF MEDICINE” (FREE)

Acute Kidney Injury in Patients with Cirrhosis Mitra K. Nadim, M.D., and Guadalupe Garcia-Tsao Acute kidney injury (AKI) is a common condition in patients with cirrhosis. It occurs in up to 50% of hospitalized patients with cirrhosis and in 58% of such patients in the intensive care unit (ICU).1-5 AKI is associated with high morbidity and mortality…

CARCINOMA EPATOCELLULARE: UNA REVISIONE OPERATIVA 2023 PER GASTROENTEROLOGI, EPATOLOGI E CHIRURGHI. DA “JAMA SURGERY”

Management of Hepatocellular Carcinoma. A Review Zachary J. Brown et al. Abstract Importance  Hepatocellular carcinoma (HCC) is the sixth most common malignancy and fourth leading cause of cancer-related death worldwide. Recent advances in systemic and locoregional therapies have led to changes in many guidelines regarding systemic therapy, as well as the possibility to downstage patients to undergo…

MA I SUPPLEMENTI CON MICRONUTRIENTI FUNZIONANO? UNA GRANDE REVISIONE PER PREVENIRE LA MALATTIA CARDIOVASCOLARE. DA “JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY” (FREE).

Micronutrient Supplementation to Reduce Cardiovascular Risk Peng An et al. ABSTRACT BACKGROUND Healthy dietary patterns are rich in micronutrients, but their influence on cardiovascular disease (CVD) risks has not been systematically quantified. OBJECTIVES The goal of this study was to provide a comprehensive and most up-to-date evidence-based map that systematically quantifies the impact of micronutrients…

DIABETE: IL NUOVO CONSENSUS REPORT DALLE ASS. AMERICANE ED EUROPEE PER LO STUDIO DEL DIABETE. SARA’ MEGLIO AGGIORNARCI ANCHE SUL DIABETE, O GASTROENTEROLOGI ED EPATOLOGI ! DA”Diabetes Care” (FREE)

Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)  Melanie J. Davies et al. The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the previous consensus statements on…

EBM E DIGNITA’: LA PRATICA CLINICA BASATA SULLA DIGNITA’ DEL PAZIENTE. OLTRE LA EBM: DA LEGGERE ! DA” THE LANCET” (FREE)

When dignity meets evidence Seye Abimbola Throughout its 40-year history, proponents of evidence-based practice, including people also advocating for dignity-based practice, have pointed at its blind spots. The need for dignity-based practice is now recognised in health care (eg, with shared decision making in caregiving and patient-determined outcome measures in research) and in health policy…