Replicating scientific results is tough — but essential A high-profile replication study in cancer biology has obtained disappointing results. Scientists must redouble their efforts to find out why. Replicabillity — the ability to obtain the same result when an experiment is repeated — is foundational to science. But in many research fields it has proved…
I Liberati’s principles dieci anni dopo ANTONIO ADDIS, LUCA DE FIORE Riassunto. A dieci anni dalla morte di Alessandro Liberati gli autori si chiedono se e quanto siano ancora importanti i principii che hanno guidato l’azione del medico e ricercatore, fondatore del centro italiano della Cochrane Collaboration. La stella polare del pensiero di Liberati può…
Hepatic encephalopathy: Thinking Beyond ammonia Hanna Blaney, M.D., M.P.H.,* and Sharon DeMorrow, Ph.D Hepatic encephalopathy (HE) is a syndrome of impaired brain function due to acute and chronic liver disease and/ or portosystemic shunting. Manifestations range from subclinical psychiatric and neurological disturbances to coma. It is associated with high morbidity and mortality and contributes to…
Gut Dysbiosis during COVID-19 and Potential Effect of Probiotics Yuan-Pin Hung et al. Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an RNA virus of the family Coronaviridae, causes coronavirus disease 2019 (COVID-19), an influenza-like disease that chiefly infects the lungs through respiratory transmission. The spike protein of SARS-CoV-2, a transmembrane protein in its outer…
Effects of Perioperative Probiotics and Synbiotics on Pancreaticoduodenectomy Patients: A Meta-Analysis of Randomized Controlled Trials Gang Tang et al. Post-pancreaticoduodenectomy infections cause mortality, morbidity, and prolonged antibiotic use. Probiotics or synbiotics may be advantageous for preventing postoperative infections, but their benefits on pancreaticoduodenectomy outcomes are controversial. This study evaluated the efficacy of probiotics and synbiotics…
Colonoscopy for Diagnostic Evaluation and Interventions to Prevent Recurrence After Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians Amir Qaseem et al. Abstract Description: The American College of Physicians (ACP) developed this guideline to provide clinical recommendations on the role of colonoscopy for diagnostic evaluation of colorectal cancer (CRC) after…