LA INDOMETACINA DA SOLA NON BASTA A PREVENIRE LA PANCREATITE DOPO ERCP: MEGLIO INSERIRE ANCHE UNA PROTESI. UN TRIAL DI NON-INFERIORITA’ AMERICANO DA “THE LANCET”

Indomethacin with or without prophylactic pancreatic stent placement to prevent pancreatitis after ERCP: a randomised non-inferiority trial Prof B Joseph Elmunze et al. Summary Background The combination of rectally administered indomethacin and placement of a prophylactic pancreatic stent is recommended to prevent pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP) in high-risk patients. Preliminary evidence suggests that…

ACCORDO TRA TRIAL CLINICI E STUDI DI COORTE ? SEMBRA MOLTO BUONO! UNO STUDIO DI META-RESEARCH DA “European Journal of Epidemiology” (FREE)

Evaluating agreement between evidence from randomised controlled trials and cohort studies in nutrition: a meta-research replication study Julia Stadelmaie et al. Abstract This meta-research study aims to evaluate the agreement of effect estimates between bodies of evidence (BoE) from RCTs and cohort studies included in the same nutrition evidence synthesis, to identify factors associated with…

OSTRUZIONE BILIARE NEOPLASTICA: DRENAGGIO PER VIA ULTRASONOGRAFICA OD ERCP? SONO EQUIVALENTI ! UNA REVISIONE SISTEMATICA DA “ACG”

EUS-Guided Vs. ERCP-Guided Biliary Drainage as Primary Approach to Malignant Distal Biliary Obstruction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Harishankar Gopakuma et al. BACKGROUND AND STUDY AIMS: Endoscopic ultrasound-guided biliary drainage (EUS-BD) is an alternative to endoscopic retrograde cholangiopancreatography (ERCP) guided transpapillary drainage in malignant distal biliary obstruction (MDBO). This meta-analysis of randomized…

TOFACITINIB RIDUCE LE COMPLICANZE OPERATORIE RISPETTO AI BIOLOGICI IN CASO DI COLECTOMIA PER COLITE ULCEROSA. UN IMPORTANTE STUDIO MULTICENTRICO ITALIANO RETROSPETTIVO DA “AJG”.

Rates of adverse events in patients with ulcerative colitis undergoing colectomy during treatment with tofacitinib vs biologics: a multicenter observational study Dragoni, Gabriele and the “TOFA-poSTOP” Study Group Abstract Background and aims: Patients with ulcerative colitis (UC) receiving immunosuppressive drugs are at substantial risk of colectomy. We aimed to assess the risk of post-operative complications…

LA DIVERSITA’ DEL MICROBIOMA PROTEGGE DAI PATOGENI BLOCCANDO LA LORO NUTRIZIONE ! UNA CONFERMA DA “SCIENCE”

Microbiome diversity protects against pathogens by nutrient blocking FRANCES SPRAGGE ET AL. Microbiome diversity protects against pathogens by nutrient blocking. Pathogens (red) fail to colonize when they overlap with the community (yellow and green bacteria) in nutrient-utilization profiles (nutrient niches are indicated by colored circles). As microbiome diversity increases, the probability that different nutrients are consumed…

MANIFESTAZIONI EXTRAINTESTINALI DELLE IBD: LE NUOVE LINEE GUIDA 2024 “ECCO”. DA “JCC” (FREE)

ECCO Guidelines on Extraintestinal Manifestations in Inflammatory Bowel Disease  Hannah Gordon et al. 1. Introduction This is the second European Crohn’s and Colitis Organisation [ECCO] evidence-based consensus on extraintestinal manifestations [EIMs] of inflammatory bowel disease [IBD] and anaemia.1 Up to 50% of patients with IBD will develop at least one EIM, which may impact each body…