VARICI ESOFAGEE: UNA REVISIONE 2022 DAL “WORLD JOURNAL OF GE” (FREE)

CIRROSI EPATICA, EPATOLOGIA, GASTROENTEROLOGIA, MEDICINA INTERNA, Senza categoria

Update on the management of gastrointestinal varices Umesha Boregowda et al. Abstract Cirrhosis of liver is a major problem in the western world. Portal hypertension is a complication of cirrhosis and can lead to a myriad of pathology of which include the development of porto-systemic collaterals. Gastrointestinal varices are dilated submucosal veins, which often develop…

IPERTENSIONE PORTALE: ULTIMA CONSENSUS DAL PROF. DE FRANCHIS ED IL GRUPPO BAVENO VII (FREE)

CIRROSI EPATICA, ENDOSCOPIA, LINEE GUIDA EBM, Senza categoria

Baveno VII – Renewing consensus in portal hypertension Roberto de Franchis et al. Summary To expand on the work of previous meetings, a virtual Baveno VII workshop was organised for October 2021. Among patients with compensated cirrhosis or compensated advanced chronic liver disease (cACLD – defined at the Baveno VI conference), the presence or absence…

CANCRO DEL PANCREAS: UNA REVIEW DA “NATURE” PER INTEGRARE OMICS E DATI CLINICI E PREDIRRE L’EVOLUZIONE

ONCOLOGIA, PANCREAS E VIE BILIARI, Senza categoria

Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data Ashton A. Connor & Steven Gallinger Abstract Pancreatic ductal adenocarcinoma (PDAC), already among the deadliest epithelial malignancies, is rising in both incidence and contribution to overall cancer deaths. Decades of research have improved our understanding of PDAC carcinogenesis, including characterizing germline predisposition, the cell of origin,…

NUOVA META-ANALISI SULLA ERADICAZIONE DELL’ HELICOBACTER PYLORI PER LA DISPEPSIA. EFFETTO DI MIGLIORAMENTO CONFERMATO, MA MODESTO: NNT 14!

GASTROENTEROLOGIA, MEDICI DI FAMIGLIA, MEDICINA INTERNA, Senza categoria

Efficacy of Helicobacter pylori eradication therapy for functional dyspepsia: updated systematic review and meta-analysis Alexander C Ford et al. Abstract Objective: Functional dyspepsia (FD) is a chronic disorder that is difficult to treat. Helicobacter pylori may contribute to its pathophysiology. A Cochrane review from 2006 suggested that eradication therapy was beneficial, but there have been numerous randomised controlled trials (RCTs)…

I TRIAL A BRACCIO SINGOLO ACCELERANO LA APPROVAZIONE DI FDA. MA SONO A FORTE RISCHIO DI BIAS E PRESENTANO EFFETTO RIDOTTO.

METODOLOGIA, REAL WORLD EVIDENCE, Senza categoria

Single-arm clinical trials that supported FDA Accelerated Approvals have modest effect sizes and at high risk of bias Tatiane Bomfim Ribeiro et al. Highlights • Single-arm trials that informed treatment approval by the FDA-AA have modest effect sizes • The lower bound of the 95% CI of 53% of approved treatments crossed the line of…

TRENT’ANNI DI EBM: UN COMMENTO DI GIULIO FORMOSO SU “RECENTI PROGRESSI IN MEDICINA” (FREE)

METODOLOGIA, REAL WORLD EVIDENCE, Senza categoria

Trent’anni di EBM: cosa è cambiato, cosa deve ancora cambiare Giulio Formoso Riassunto. In generale, medicina basata sulle prove e pratica clinica non devono essere viste come due entità in contrapposizione. La prima suggerisce alcune regole per la realizzazione e la interpretazione degli studi, con l’obiettivo di migliorare la salute del maggior numero possibile di…