I PRIMI 100 GIORNI DEL COVID-19: LA EBM RISCHIA LA “DEBACLE”

Recruitment and Results Reporting of COVID-19 Randomized Clinical Trials Registered in the First 100 Days of the Pandemic Perrine Janiaud, et al Overall, 30% of COVID-19 RCTs initiated in the first 100 days of the pandemic did not begin recruitment, and only 10% had results reported by mid-October, suggesting the possibility of substantial research waste…

Riapre il portale EVIDENCE BASED GASTROENTEROLOGY & HEPATOLOGY (EBGH)

Cara Amica, caro Amico, con le riaperture riapre anche il portale EVIDENCE BASED GASTROENTEROLOGY & HEPATOLOGY (EBGH). Abbiamo ripreso naturalmente tutte le letture dell’ultimo Corso del Laboratorio di Epidemiologia, tenutosi lo scorso Dicembre 2019, con le slide e l’audio. Le troverai nella sezione Corsi di Torgiano. Vedrai inserite anche le aree tematiche sulla Cirrosi, sulla…

CLIPPING PER EMORRAGIA ACUTA SEVERA DA DIVERTICOLI: QUALE RUOLO? E DOPO PULIZIA?

Severe Acute Colonic Diverticular Bleeding: The Efficacy of Rapid Bowel Preparation With 1 L Polyethylene Glycol Ascorbate Solution and Direct Endoscopic Hemoclipping for Successful Hemostasis Adnan Malik, et al. ABSTRACT Colonic diverticular bleeding is an established cause of painless acute lower gastrointestinal hemorrhage. Colonoscopy, performed within 24 hours of presentation, is the usual initial diagnostic…

Dalla RWE alle strategie di prevenzione: le disuguaglianze di salute negli immigrati residenti in una ASL italiana

From the “real-world evidence” to prevention strategies: health inequalities in immigrants residing in an Italian Local Health Unit Mario Muselli1,  Vincenza Cofini1 ,  Chiara Berra1,  Cristina Carmignani1,  Leondino Mammarella2,  Stefano Necozione1 Department of Life, Health and Environmental Sciences, University of L’Aquila (Italy) Local Health Unit No.1 Avezzano-Sulmona-L’Aquila, L’Aquila (Italy) ABSTRACT OBJECTIVES: to assess the health inequalities of immigrants in the…

Generazione di RWE da note cliniche non strutturate per esaminare l’utilità clinica dei test genetici: caso d’uso in BRCAness

Generating real-world evidence from unstructured clinical notes to examine clinical utility of genetic tests: use case in BRCAness Yiqing Zhao1, Saravut J Weroha2, Ellen L Goode3, Hongfang Liu1, Chen Wang4 Abstract Background: Next-generation sequencing provides comprehensive information about individuals’ genetic makeup and is commonplace in oncology clinical practice. However, the utility of genetic information in the clinical decision-making process has…

La Real World Evidence richiede un’attenta interpretazione

Real-world Evidence Needs Careful Interpretation Peter Nash The Journal of Rheumatology January 2021, 48 (1) 1-2; DOI: https://doi.org/10.3899/jrheum.201004 The Janus kinase (JAK) inhibitors have proven to be popular across the globe for an increasing variety of autoimmune inflammatory disorders seen in rheumatology, dermatology, and gastroenterology1. In patients with rheumatoid arthritis (RA), market share is on the rise in many countries,…