Conflitto d’interessi nello sviluppo delle linee guida
Conflicts of Interest Ethics: Silencing Expertise in the Development of International Clinical Practice GuidelinesDerek J. Jones, Alan N. Barkun, Yidan…
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La magnitudo dell’effect size di molti indici prognostici è sovrastimata
Comparison of effect sizes associated with biomarkers reported in highly cited individual articles and in subsequent meta-analyses.Ioannidis JP, Panagiotou OA.…
Come utilizzare un articolo per migliorare la qualita’ degli interventi clinici
How to use an article about quality improvement. Fan E, Laupacis A, Pronovost PJ, Guyatt GH, Needham DM. JAMA. 2010…
PHQ12 score predittore di severità dei sintomi e necessità di intervento medico in pz affetti da IBS e malattia diverticolare
The Patient Health Questionnaire 12 Somatic Symptom scale as a predictor of symptom severity and consulting behaviour in patients with…
Review sul reporting dei bias nella letteratura medica
Reporting bias in medical research – a narrative review.McGauran N, Wieseler B, Kreis J, Schuler YB, Kolsch H, Kaiser T.…
RCT nei farmaci antineoplastici : nuove regole?
Incremental advance or seismic shift? The need to raise the bar of efficacy for drug approval.Sobrero A, Bruzzi P. J…
Metodologia da applicare negli RCT su sanguinamenti UGI
Methodology for Randomized Trials of Patients With Nonvariceal Upper Gastrointestinal Bleeding: Recommendations From an International Consensus Conference.Laine L, Spiegel B,…
Errori nel condurre review sistematiche sulla terapia dell’IBS
Errors in the Conduct of Systematic Reviews of Pharmacological Interventions for Irritable Bowel Syndrome.Ford AC, Guyatt GH, Talley NJ, Moayyedi…
Randomized clinical trials for comparative effectiveness research
Rethinking randomized clinical trials for comparative effectiveness research: the need for transformational change.Luce BR, Kramer JM, Goodman SN, Connor JT,…
Comparative effectiveness research
Comparative effectiveness research: a report from the Institute of Medicine.Sox HC, Greenfield S. Ann Intern Med. 2009 Aug 4;151(3):203-5. On…
Calcolatore per valutare la sopravvivenza nel K colon
Practical Application of a Calculator for Conditional Survival in Colon Cancer.Chang GJ, Hu CY, Eng C, Skibber JM, Rodriguez-Bigas MA.…
Predire il rischio di morte con i comuni esami di laboratorio: è possibile costruire uno score ?
Exceptional mortality prediction by risk scores from common laboratory tests.Horne BD, May HT, Muhlestein JB, Ronnow BS, Lappé DL, Renlund…
La qualità degli studi osservazionali può inficiare i risultati delle M-A
Does quality of observational studies affect the results of a meta-analysis?: the case of cigarette smoking and pancreatic cancer.La Torre…
La qualità degli studi osservazionali può inficiare i risultati delle M-A
Does quality of observational studies affect the results of a meta-analysis?: the case of cigarette smoking and pancreatic cancer.La Torre…
Linee guida spesso basate su evidenze inconclusive ….
Scientific evidence underlying the ACC/AHA clinical practice guidelines.Tricoci P, Allen JM, Kramer JM, Califf RM, Smith SC Jr. JAMA. 2009…
Aggiornamento professionale via internet : una meta-analisi
Internet-based learning in the health professions: a meta-analysis.Cook DA, Levinson AJ, Garside S, Dupras DM, Erwin PJ, Montori VM. JAMA.…
Review sistematica sull’accuratezza diagnostica dei test
Systematic reviews of diagnostic test accuracy.Leeflang MM, Deeks JJ, Gatsonis C, Bossuyt PM; Cochrane Diagnostic Test Accuracy Working Group. Ann…
Quando un test diventa un refernce standard?
When should a new test become the current reference standard?Glasziou P, Irwig L, Deeks JJ. Ann Intern Med. 2008 Dec…
Le preferenze dei pazienti possono condizionare i risultati dei trial
Patients’ preferences within randomised trials: systematic review and patient level meta-analysis . Preference Collaborative Review Group .BMJ 2008;337:a1864 Objective To…
Test ripetitivi possono inficiare le meta-analisi
Apparently conclusive meta-analyses may be inconclusive – Trial sequential analysis adjustment of random error risk due to repetitive testing of…
Lo strumento AGREE per valutare la qualità delle linee guida
Development and validation of an international appraisal instrument for assessing the quality of clinical practice guidelines: the AGREE project. AGREE…
GRADE: un nuovo strumento per valutare la qualità delle linee guida
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. Guyatt GH, Oxman AD, Vist GE, Kunz…
Valutazioni economiche necessarie nel formulare raccomandazioni
Incorporating considerations of resources use into grading recommendations.Guyatt GH, Oxman AD, Kunz R, Jaeschke R, Helfand M, Liberati A, Vist…
Dall’evidenza alle raccomandazioni……
Going from evidence to recommendations .Gordon H Guyatt, Andrew D Oxman, Regina Kunz, Yngve Falck-Ytter, Gunn E Vist, Alessandro Liberati,…