COME DIAVOLO SPIEGARE QUANTO E’ BASSA LA PROBABILITA’ DI COMPLICAZIONI DA VACCINO ANTI COVID-19 ? IL CASO DELLA TROMBOSI POST-VACCINO AL CONFRONTO CON DECESSO DA ANESTESIA, MORTALITA’ SUL LAVORO O DA INCIDENTE STRADALE

Understanding one in 100,000 What does this tiny probability look like? Anthony B. Masters The EMA stated there was a plausible link between the Oxford-AstraZeneca (Vaxzevria) vaccine and rare blood clots. The European Medicines Agency said the probability of this kind of blood clot was “very low”. With millions vaccinated, very rare side effects can emerge. The Paul-Ehrlich-Institut reported…

DIVERTICOLITE SIGMOIDEA: UNA REVISIONE DAL WORLD J. OF GASTROENTEROLOGY

Update on the management of sigmoid diverticulitis Mark H Hanna, Andreas M Kaiser Abstract Diverticular disease and diverticulitis are the most common non-cancerous pathology of the colon. It has traditionally been considered a disease of the elderly and associated with cultural and dietary habits. There has been a growing evolution in our understanding and the…

SEQUENZA DI TERAPIE E STUDIO CONTROLLATO: LO “STEPPED WEDGE TRIAL”. UNA OCCASIONE PER GLI STUDI SUL COVID ? E PER LE MALATTIE AD ORIGINE COMPLESSA COME LE IBD O LA IBS?

Key concepts in clinical epidemiology: Stepped wedge trials Richard Hooper Abstract A stepped wedge trial evaluates an intervention that is implemented over a number of time periods according to a staggered timetable. Stepped wedge trials are usually cluster randomized, the intervention being delivered at some geographical, service or other cluster level. There is considerable variety…

SORVEGLIANZA E GESTIONE DELLA DISPLASIA COLORETTALE IN CORSO DI IBD: UNA REVISIONE AGA DA ESPERTI

AGA Clinical Practice Update on Endoscopic Surveillance and Management of Colorectal Dysplasia in Inflammatory Bowel Diseases: Expert Review Sanjay K. Murthy et al. Improvements in disease management, as well as endoscopic technology and quality, have dramatically changed the way in which we conceptualize and manage inflammatory bowel disease–related dysplasia over the past 20 years. Based…

NNT: PER COMBINARE BENEFICI E RISCHI NASCE “NNT PER EFFETTO NETTO” , UNA STATISTICA INTELLIGENTE DALLA McMASTER !

The number needed to treat for net effect (NNTnet) as a metric for measuring combined benefits and harms Guowei Lia et al. Abstract Calculating the number needed to treat (NNT) has been widely used to help understand treatment effect results of randomized controlled trials (RCTs). Combined benefit and harm profiles from RCT results have to…