IL BENEFICIO IN TERMINI DI SOPRAVVIVENZA E’ RIDOTTO AD ASSENTE PER I FARMACI ONCOLOGICI APPROVATI : L’ESPERIENZA CANADESE

Evaluation of the Clinical Benefit of Cancer Drugs Submitted for Reimbursement Recommendation Decisions in Canada Daniel E. Meyers et al. IMPORTANCE Cancer drugs approved by the US Food and Drug Administration have come under scrutiny for marginal clinical benefits; however, the clinical benefits of cancer drugs recommended for reimbursement in Canada have not been adequately…

ABSOLUTE RISK O RELATIVE RISK ? PER SENSIBILIZZARE IL PUBBLICO SUI VACCINI E’ MEGLIO IL RISCHIO RELATIVO?

Relative risk rather than absolute risk reduction should be preferred to sensitise the public to preventive actions: letter   Nicolas Chapelle et al. We thank Lawrence and colleagues1 for their interest in our work,2 about which they raised some comments as the need of expressing results in absolute rather than relative risks. As they appropriately mentioned in…

COVID-19: UNA “LIVING” REVISIONE SISTEMATICA DAL DIPARTIMENTO DI EPIDEMIOLOGIA DELLA REGIONE LAZIO.

L’elogio dell’incertezza: una revisione sistematica living per valutare l’efficacia e la sicurezza dei trattamenti farmacologici per pazienti affetti da covid-19 FABIO CRUCIANI et al. Riassunto. Introduzione. Il SARS-CoV-2 è un coronavirus che causa una malattia che può evolvere in una polmonite interstiziale potenzialmente letale. A dicembre 2020 in Italia più di 2 milioni di persone hanno…

MICROBIOMA E PARKINSON: UNA GRANDE META-ANALISI !

Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation Stefano Romano et al. Abstract The gut microbiota is emerging as an important modulator of neurodegenerative diseases, and accumulating evidence has linked gut microbes to Parkinson’s disease (PD) symptomatology and pathophysiology. PD is often preceded by gastrointestinal symptoms and alterations of the…

LA DIVERTICOLITE: UNA OTTIMA REVISIONE DAL BMJ (MA IL DECLASSAMENTO DELLE EVIDENZE PER LA TERAPIA MEDICA DI PREVENZIONE NON E’ CORRETTO)

Management of colonic diverticulitis Anne F Peery ABSTRACT   Left sided colonic diverticulitis is a common and costly gastrointestinal disease in Western countries, characterized by acute onset of often severe abdominal pain. Imaging is necessary to make an initial diagnosis and determine disease severity. Colonoscopy should be done six to eight weeks after diagnosis to…