COME EVITARE LA PROSSIMA PANDEMIA. TORNA IL BILL GATES ‘S PENSIERO. DA “THE ECONOMIST”. (FREE).

Bill Gates explains “How to Prevent the Next Pandemic” His proposals for nipping infections in the bud are worth exploring How to Prevent the Next Pandemic. By Bill Gates. Knopf; 304 pages; $28. Allen Lane; £25 First, the climate. Next, plagues. Bill Gates’s career-switch from entrepreneur and philanthropist to crusading author is developing nicely. It is just over a year…

CHIRURGHI DEL PANCREAS ATTENZIONE: UN NUOVO APPROCCIO PER IDENTIFICARE PRECOCEMENTE LE COMPLICANZE DOPO UNA RESEZIONE PANCREATICA. LA MORTALITA CROLLA DEL 50%!UN GRANDE TRIAL NEI PAESI BASSI. DA “LANCET”

Algorithm-based care versus usual care for the early recognition and management of complications after pancreatic resection in the Netherlands: an open-label, nationwide, stepped-wedge cluster-randomised trial F Jasmijn Smits, MD  et al. Summary Background Early recognition and management of postoperative complications, before they become clinically relevant, can improve postoperative outcomes for patients, especially for high-risk procedures…

ORGAN FAILURE: RIPESCARE IL MODELLO LINFA-INTESTINO? DA “JAMA SURGERY” (FREE)

The Gut-Lymph Model Gives New Treatment Strategies for Organ Failure John A. Windsor et al. Organ Failure Remains an Unmet Global Challenge   Each year, more than 20 million people with organ failure (OF) are admitted to intensive care units around the world.1 With a 30% mortality rate, it remains the leading cause of death in intensive…

ASPIRINA PER LA PREVENZIONE PRIMARIA CARDIOVASCOLARE E DEL CANCRO COLORETTALE. UN MODELLO AGGIORNATO DALLE LINEE GUIDA AMERICANE. DA “JAMA” (FREE).

Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Updated Modeling Study for the US Preventive Services Task Force Steven P. Dehmer et al. Abstract Importance  The US Preventive Services Task Force (USPSTF) is updating its 2016 recommendation on the use of aspirin for the primary prevention of cardiovascular disease (CVD) and colorectal cancer (CRC). Objective  To provide…

LA ASPIRINA PER LA PREVENZIONE PRIMARIA CARDIOVASCOLARE E’ TORNATA! LE NUOVE LINEE GUIDA DA “JAMA CARDIOLOGY”. UN EDITORIALE (FREE).

USPSTF Report on Aspirin for Primary Prevention Donald M. Lloyd-Jones  As with many therapies in modern medicine, aspirin for the primary prevention of atherosclerotic cardiovascular disease (ASCVD) is neither all good nor all bad. Specifically, aspirin may benefit selected patients, but that comes at the price of a narrower therapeutic window than desirable because of the…

RISCHIO DI EMORRAGIA CON NOAC + CORTISONICI . DAL “DRUG AND THERAPEUTIC BULLETTIN (BMJ)” (FREE).

Risk of gastrointestinal bleeding with concomitant NOAC and glucocorticoid treatment Abstract Overview of: Holt A, Blanche P, Zareini B, et al. Gastrointestinal bleeding risk following concomitant treatment with oral glucocorticoids in patients on non-vitamin K oral anticoagulants. Heart. doi:10.1136/heartjnl-2021-319503 [Epub ahead of print 13 Aug 2021]. Key learning points The risk of gastrointestinal (GI) bleeding when oral glucocorticoids…