ATTENZIONE ! I SINTOMI LARINGOFARINGEI IN SOSPETTA MALATTIA DA REFLUSSO POSSONO REAGIRE ALLA LOGOTERAPIA! DA “AMERICAN JOURNAL OF GASTROENTEROLOGY”.

Laryngeal Recalibration Therapy Improves Laryngopharyngeal Symptoms in Patients with Suspected Laryngopharyngeal Reflux Disease. Erin Walsh et al. BACKGROUND: Laryngopharyngeal symptoms such as cough, throat clearing, voice change, paradoxic vocal fold movement or laryngospasm are hyper-responsive behaviors resulting from local irritation (e.g., refluxate) and heightened sympathetic tone. Laryngeal recalibration therapy (LRT) guided by a speech-language pathologist (SLP)…

HBV: LE ULTIME NOTIZIE SULLA TERAPIA. UNA OTTIMA, RAPIDA REVIEW DA HONG-KONG. DA “CLINICAL LIVER DISEASE (AASLD)” (FREE)

Therapeutic advances in HBV cure Rex Wan-Hin Hui et al. INTRODUCTION Despite efforts in hepatitis control, chronic HBV infection remains a major cause of liver-related morbidity and mortality globally.[1] HBV integration into the human genome and covalently closed circular DNA persistence are barriers to the sterilizing cure of HBV.[1] Functional cure, defined as sustained HBsAg…

E’ OPPORTUNO UN MODELLO A “FIXED-EFFECT” O A “RANDOM EFFECT” PER LA TUA META-ANALISI? UNA GRANDE, RAPIDA “SPIEGA” DA GORDON GUYATT! DAL “CHINESE MEDICAL JOURNAL” /FREE)

Fixed-effect and random-effects models in meta-analysis Zhai, Chunjuan; Guyatt, Gordon A systematic review synthesizes evidence addressing a structured clinical question using systematic and explicit methods to search, identify, screen, critically appraise, and extract and analyze data from relevant studies.[1] A meta-analysis, on the other hand, is a statistical method that combines the quantitative results of available…

CROHN’S DISEASE: L’IMPATTO DELL’APPROCCIO CON IMMUNOSOPPRESSORI ED ANTI-TNF NEL POST-OPERATORIO IN UNO STUDIO MULTICENTRICO DI “REAL WORLD”, COORDINATO DAL S. FILIPPO NERI DI ROMA. DA”ALIMENTARY PHARMACOLOGY & THERAPEUTICS”

Crohn’s disease after surgery: Changes in post-operative management strategies over time and their impact on long-term re-operation rate—A retrospective multicentre real-world study Annalisa Aratari et al. Summary Background Few data are available addressing the impact of post-operative management of Crohn’s disease (CD) on long-term clinical course. Aim To assess the evolution of post-operative management strategies…

CROHN’S DISEASE: L’APPROCCIO TOP-DOWN E’ SUPERIORE ALLO STEP-UP ! “PROFILE” : UN GRANDE TRIAL RANDOMIZZATO MULTICENTRICO. DA “LANCET GASTROENTEROLOGY & HEPATOLOGY” (FREE)

A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn’s disease (PROFILE): a multicentre, open-label randomised controlled trial Nurulamin M Noor, et al. Summary Background Management strategies and clinical outcomes vary substantially in patients newly diagnosed with Crohn’s disease. We evaluated the use of a putative prognostic biomarker to…

ISCHEMIA MESENTERICA CRONICA: MEGLIO LE PROTESI COPERTE ! UN DIFFICILE GRANDE TRIAL OLANDESE DA “LANCET GASTROENTEROLOGY & HEPATOLOGY”

Covered versus bare-metal stenting of the mesenteric arteries in patients with chronic mesenteric ischaemia (CoBaGI): a multicentre, patient-blinded and investigator-blinded, randomised controlled trial Luke G Terlouw et al.† Summary Background Mesenteric artery stenting with a bare-metal stent is the current treatment for atherosclerotic chronic mesenteric ischaemia. Long-term patency of bare-metal stents is unsatisfactory due to…