LA PERFORMANCE DEI TEST MERITA NUOVA ATTENZIONE! DA “NEJM EVIDENCE)

Assessing Diagnostic Performance Karen Cosby,et al. Diagnosis is fundamental to medicine, both as an action and as a goal. Clinical diagnosis is an exercise in classification; that is, placing the patient’s condition in the correct diagnostic category. However, this seemingly straightforward task — to determine the correct diagnosis —has many facets that often make assessing…

LA TERAPIA DELLA INSUFFICIENZA EPATICA ACUTA SU CRONICO. UNA OTTIMA REVIEW CON IL RUOLO DELLA ALBUMINA. DA “SEMINARS IN LIVER DISEASE” (FREE)

Novel Therapeutic Approaches in Treatment of Acute-on-Chronic Liver Failure Mohammad Mahdi Saeidinejad et al. Abstract Acute-on-chronic liver failure (ACLF), a clinical syndrome that can develop at any stage in the progression of cirrhotic liver disease, is characterized by an acute decompensation in liver function with associated multiorgan failure and high short-term mortality. Current evidence points…

CALPROTECTINA FECALE : QUALE PERFORMANCE DIAGNOSTICA NEL DIFFERENZIARE IBD DA IBS? LA PERFORMANCE E’ OTTIMA : UNA GRANDE REVIEW TUTTA ITALIANA SU 17 STUDI. DA” AT&P” (FREE)

Systematic review with meta-analysis: Diagnostic performance of faecal calprotectin in distinguishing inflammatory bowel disease from irritable bowel syndrome in adults Elton Dajt et al. Summary Background Symptoms of inflammatory bowel disease (IBD) often overlap with those of irritable bowel syndrome (IBS). Aim To evaluate the diagnostic performance of faecal calprotectin in distinguishing patients with IBD…

COME AGGIUNGERE UN NUOVO TRIAL AD UNA REVISIONE DELLA LETTERATURA PRECEDENTE? OTTIMI CONSIGLI DA PAUL GLASZIOU! DA “BMJ EVIDENCE -BASED MEDICINE” (FREE)

Setting new research in the context of previous research: some options   Paul Glasziou et al. Introduction If a new clinical trial is to be justifiable both scientifically and ethically it should be designed in the light of an assessment of relevant previous research, ideally a systematic review. When its findings are reported, these should…

CEA NELLA DIAGNOSI DELE CISTI MUCINOSE DEL PANCREAS. UNO STUDIO OSSERVAZIONALE SU 1169 PZ SUGGERISCE DI AUMENTARE LA SPECIFICITA’ ELEVANDO LA SOGLIA SOPRA I 250ng/ml. DA “GUT”

Revisiting the performance of cyst fluid carcinoembryonic antigen as a diagnostic marker for pancreatic mucinous cysts: a comprehensive 20-year institutional review Melanie C Kwan et al. Abstract Objective Elevated pancreatic cyst fluid carcinoembryonic antigen (CEA) has been routinely used to classify mucinous cysts. This study incorporates original data that established the CEA ≥192 ng/mL threshold with over…

LA SORVEGLIANZA DEI SOGGETTI AD ALTO RISCHIO PORTA ALLA IDENTIFICAZIONE PRECOCE DEL CANCRO DEL PANCREAS! UN GRANDE STUDIO MULTICENTRICO ITALIANO SU 524 PAZIENTI. DA” Am J Gastroenterol”

Outcomes of a 3-year prospective surveillance in individuals at high-risk for pancreatic cancer Salvatore Paiella, Gabriele Capurso et al. Abstract Introduction: Pancreatic cancer (PC) surveillance of high-risk individuals (HRI) is becoming more common worldwide, aiming at anticipating PC diagnosis at a pre-clinical stage. In 2015 the Italian Registry of Families at Risk of Pancreatic Cancer (IRFARPC) was…