ULCERA DA STRESS: SONO UTILI I PPI? UNA META-ANALISI CANADESE (2024). DA “NEJM EVIDENCE”.

Proton-Pump Inhibitors to Prevent Gastrointestinal Bleeding — An Updated Meta-Analysis  Ying Wang et al BACKGROUND The goal of this systematic review was to examine the efficacy and safety of proton-pump inhibitors for stress ulcer prophylaxis in critically ill patients. METHODS We included randomized trials comparing proton-pump inhibitors versus placebo or no prophylaxis in critically ill…

ULCERA DA STRESS: SONO UTILI I PPI? UN OTTIMO TRIAL MULTICENTRICO CANADESE. DA “NEJM”

Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation Deborah Cook et al. Abstract Background: Whether proton-pump inhibitors are beneficial or harmful for stress ulcer prophylaxis in critically ill patients undergoing invasive ventilation is unclear. Methods: In this international, randomized trial, we assigned critically ill adults who were undergoing invasive ventilation to receive intravenous pantoprazole (at a dose of…

MUTIMORBIDITA’ ED EBM: UN NUOVO APPROCCIO PER TUTTI NOI (E PER IL MEDICO DI FAMIGLIA). DA “SENSIBLE MEDICINE” (FREE) (ISCRIVETEVI A SENSIBLE MEDICINE!)

What multimorbidity shows us about guideline-driven evidence-based medicine MARIANA BAROSA MAR 19, 2024 Primary care physicians are increasingly voicing concerns about the guideline-driven paradigm of clinical practice. At the root of these concerns lies a tension between what physicians think is the ideal way of practising medicine and how that ideal has been implemented: a…

STATINE PER LA MALATTIA CRONICA DEL FEGATO ? CORRETE ALLA META-ANALISI 2024 IN CORSO DI STAMPA! DA “Semin Liver Dis”

Statins in chronic liver disease: review of literature and future role Nguyen Pham, Jihane N Benhammou Abstract Chronic liver disease (CLD) is a major contributor to global mortality, morbidity, and healthcare burden. Progress in pharmacotherapeutic for CLD management is lagging given its impact on the global population. While statins are indicated for the management of…

ACIDO OBETICOLICO NELLA COLANGITE BILIARE PRIMARIA. UN OTTIMO SCORE VALIDATO PER PREDIRE LA RISPOSTA CLINICA ! DA “Clin Gastroenterol Hepatol”.

Development and validation of a scoring system to predict response to obeticholic acid in primary biliary cholangitis Antonio De Vincentis et al Abstract Background & aims: Obeticholic acid (OCA) is the only licensed second-line therapy for primary biliary cholangitis (PBC). With novel therapeutics in advanced development, clinical tools are needed to tailor the treatment algorithm. We aimed…

PANCREATITE ACUTA : LE NUOVE LINEE GUIDA 2024 DELL’AMERICAN COLLEGE OF GASTROENTEROLOGY! DA “AJG” (FREE)

American College of Gastroenterology Guidelines: Management of Acute Pancreatitis Tenner, Scott et al. Abstract Acute pancreatitis (AP), defined as acute inflammation of the pancreas, is one of the most common diseases of the gastrointestinal tract leading to hospital admission in the United States. It is important for clinicians to appreciate that AP is heterogenous, progressing…