I BOLLETTINI INDIPENDENTI SUI FARMACI SONO LA RISPOSTA ALLA EPIDEMIA INFORMATICA! COME QUESTO! CONTINUATE A SEGUIRCI (FREE)

From info-desert to info-demic: the role of independent drug bulletins David Phizackerley James A Cave n the late 1950s and early 1960s independent drug bulletins first began to be published. At that time, laws on the licensing of medicines had yet to be introduced, there was little effective control of marketing and promotion of medicines,…

I DUE NUOVI ANTIVIRALI PER IL COVID-19: MOLNUPIRAVIR E NIRMATRELVIR/RITONAVIR . DAL “DRUG AND THERAPEUTIC BULLETTIN (BMJ)”(FREE)

Two new oral antivirals for covid-19: ▼molnupiravir and ▼nirmatrelvir plus ritonavir   Abstract This article is made freely available for personal use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial…

COCHRANE REVIEWS: LA MAGGIOR PARTE DEGLI INTERVENTI SANITARI SEGNALATI NON SONO EFFICACI SE VALUTATI PER EVIDENZA DI ELEVATA QUALITA’. IL GRUPPO DI JOANNIDIS COLPISCE ANCORA

Most healthcare interventions tested in Cochrane Reviews are not effective according to high quality evidence: a systematic review and meta-analysis JeremyHowick et al. Highlights • In this large sample of 1567 interventions studied within Cochrane reviews, effects of most interventions (94%) interventions were not supported by high quality evidence. • Potential harms of healthcare interventions…

ENCEFALOPATIA GRADO 3-4: METABOLITI DI ORIGINE BATTERICA, E BASSI LIVELLI DI ISOLEUCINA, TIROSINA E LISOFOSFOLIPIDI SONO PREDITTIVI DI BRAIN FAILURE.

Admission Serum Metabolites and Thyroxine Predict Advanced Hepatic Encephalopathy in a Multi-center Inpatient Cirrhosis Cohort Jasmohan S Bajaj et al. Abstract: Background and Aims Grade 3-4 hepatic encephalopathy (advanced HE), also termed brain failure (BF), is an organ failure that defines acute-on chronic liver failure. It is associated with poor outcomes in cirrhosis but cannot…

EPATOCARCINOMA DA EPATITE CRONICA DA VIRUS B. ENTECAVIR vs TENOFOVIR. UNA COORTE NAZIONALE DALLA COREA. “JAMA ONCOLOGY” (FREE)

Risk of Hepatocellular Carcinoma in Patients Treated With Entecavir vs Tenofovir for Chronic Hepatitis B A Korean Nationwide Cohort Study Jonggi Choi, M et al. IMPORTANCE Entecavir and tenofovir disoproxil fumarate have comparable efficacy in achieving surrogate end points, including virologic response, and are equally recommended as first-line treatments for patients with chronic hepatitis B…

INSUFFICIENZA ACUTA EPATICA SU CRONICO: L’ULTIMA LINEA GUIDA DAL GRUPPO DI BAJAJ. “AMERICAN J. OF GASTROENTEROLOGY” 2022 (FREE)

Acute-on-Chronic Liver Failure Clinical Guidelines Jasmohan S. Bajaj et al. In patients with cirrhosis and chronic liver disease, acute-on-chronic liver failure is emerging as a major cause of mortality. These guidelines indicate the preferred approach to the management of patients with acute-on-chronic liver failure and represent the official practice recommendations of the American College of…