EPATITE CRONICA DA VIRUS B. DUSHEIKO E COLL. SUI NUOVI APPROCCI ! DA “NEJM” (FREE).

CIRROSI EPATICA, EPATOLOGIA, EPATOLOGIA ONCOLOGICA, Senza categoria

New Approaches to Chronic Hepatitis B Geoffrey Dusheiko et al. Chronic hepatitis B is caused by the hepatitis B virus (HBV), a hepatotropic DNA virus that can replicate at high levels and cause minimal disease or severe liver injury. The clinical spectrum of chronic hepatitis B ranges from no symptoms to progressive hepatic fibrosis, advanced…

DVQOL: UN NUOVO PARAMETRO PER MISURARE LA QUALITA’ DI VITA DEL PAZIENTE CON MALATTIA DIVERTICOLARE. DA “ANNALS OF SURGERY” (FREE)

GASTROENTEROLOGIA, MALATTIA DIVERTICOLARE

What’s in a Number? Assessing the Burden of Diverticular Disease Mariam N. Hantouli et al. INTRODUCTION Annually, nearly 3 million Americans are diagnosed with diverticulitis, and 1 in 4 have recurrent episodes.1,2 The American Society of Colon and Rectal Surgeons recommends individualizing the decision to operate based on the impact of diverticular disease on quality of…

IL RITIRO DEI PAPER PUBBLICATI E’ ARRIVATO A 5.000 NEL 2022. SIAMO NEI GUAI? DA “RETRACTION WATCH”

EVIDENCE CORNER, INTERNATIONAL SNAPSHOTS, METODOLOGIA, REAL WORLD EVIDENCE, Senza categoria

Nearing 5,000 retractions: A review of 2022 Retractions of a given year’s publications as a percentage of papers published in science and engineering. Retraction data from Retraction Watch Database, overall publication figures via U.S. NSF. In 2002, journals retracted 119 papers from the scientific literature. What a difference two decades make. On several occasions this…

RNA SEQUENCING: CONE FUNZIONE LA TECNICA DIAGNOSTICA. DA JAMA.

EPATOLOGIA, GASTROENTEROLOGIA, MEDICINA INTERNA, METODOLOGIA, Senza categoria

RNA Sequencing as a Diagnostic Tool Shamika Ketkar et al.     RNA sequencing (RNA-seq) is a new tool in the genetic diagnostic laboratory made possible by the advent of low-cost, high-throughput, next-generation sequencing technology. Historically, RNA studies were limited to gene expression using microarray technology for the detection of gene rearrangements and quantification of gene expression for predefined…

CARI GASTROENTEROLOGI ED INTERNISTI, FORSE PER GESTIRE I VOSTRI PAZIENTI E’ MEGLIO RIVEDERE UN PO’ I DISTURBI DI ANSIA . DA JAMA .

DISORDINI FUNZIONALI, DISPEPSIA, MEDICI DI FAMIGLIA, MEDICINA INTERNA, Senza categoria

Anxiety Disorders: A Review Kristin L. Szuhany; Naomi M. Simon Importance  Anxiety disorders have a lifetime prevalence of approximately 34% in the US, are often chronic, and significantly impair quality of life and functioning. Observations  Anxiety disorders are characterized by symptoms that include worry, social and performance fears, unexpected and/or triggered panic attacks, anticipatory anxiety, and avoidance behaviors.…

IL COSIDDETTO “TARGET TRIAL”: DAI DATI OSSERVAZIONALI AL TRIAL SIMULATO. UDITE, UDITE! E RISPARMIATE ! DAL “BMJ” (FREE).

METODOLOGIA, REAL WORLD EVIDENCE, Senza categoria

Target trial emulation: applying principles of randomised trials to observational studies Anthony A Matthews et al.   “using observational data to emulate a target trial”   The randomised trial is the preferred study design for evaluating the effectiveness and safety of interventions. Yet such trials can be prohibitively expensive, unethical, or take too long. When…