PREVENZIONE DELL’HCC CON FANS ED ANTI-AGGREGANTI: UNA GRANDE META-ANALISI DA APT

Systematic review with meta-analysis: The effects of non-steroidal anti-inflammatory drugs and anti-platelet therapy on the incidence and recurrence of hepatocellular carcinoma Regina Zi Hwei Ta et al. Background: Chemoprevention with NSAIDs, including aspirin, and anti-platelet therapy (APT), has been suggested to reduce the incidence and recurrence of hepatocellular carcinoma (HCC). Aim: To determine by meta-analysis whether NSAIDs…

CANCRO DEL PANCREAS: UNA GRANDE REVIEW DA JAMA

Pancreatic Cancer A Review Wungki Park et al. IMPORTANCE Pancreatic ductal adenocarcinoma (PDAC) is a relatively uncommon cancer, with approximately 60 430 new diagnoses expected in 2021 in the US. The incidence of PDAC is increasing by 0.5% to 1.0% per year, and it is projected to become the second-leading cause of cancer-related mortality by…

LA STEATOSI NON ALCOLICA (NASH) AUMENTA IL RISCHIO DI EVENTI CARDIOVASCOLARI. UNA META-ANALISI DAL GRUPPO ITALIANO DI VERONA SU “LANCET”

Non-alcoholic fatty liver disease and risk of fatal and non-fatal cardiovascular events: an updated systematic review and meta-analysis Alessandro Mantovan et al. Summary Background Studies have reported a significant association between non-alcoholic fatty liver disease (NAFLD) and increased incidence of cardiovascular disease (CVD). However, the magnitude of the risk and whether this risk changes with…

ANCORA SUL VALORE DELLA “P”. UNA INTERPRETAZIONE BAYESIANA DELLA SIGNIFICATIVITA’ !

Bayesian interpretation of p values in clinical trials   John Ferguson Abstract Commonly accepted statistical advice dictates that large-sample size and highly powered clinical trials generate more reliable evidence than trials with smaller sample sizes. This advice is generally sound: treatment effect estimates from larger trials tend to be more accurate, as witnessed by tighter…

I FARMACI ANTIDIABETICI PER LA STEATOSI NON ALCOLICA IN CORSO DI DIABETE: UNA META-ANALISI “NETWORK”

Anti-Diabetic Medications for Type 2 Diabetics with Non-Alcoholic Fatty Liver Disease. Evidence from a Network Meta-Analysis of Randomised Controlled Trials Cheng Han Ng, et al. Highlights • PPARγ agonists was ranked the best treatment for steatosis reduction. • SLGT2i was ranked the best treatment for fibrosis reduction • GLP-1RA and SGLT2i are superior for BMI reduction…

I MIGLIORI 10 PAPERS SULLA EBM (E PER INSEGNARLA!): IL WORKSHOP “SICILIA 2019” IN COLLABORAZIONE CON IL GRUPPO ITALIANO EBM

TEN PAPERS FOR TEACHERS OF EVIDENCE-BASED MEDICINE AND HEALTH CARE. THE SICILY WORKSHOP 2019 David Nunan et al. Introduction A previous article sought to signpost papers that were considered helpful when starting on the journey of practicing evidence-based medicine (EBM).1 The lead author was invited to run a workshop at the Eighth Conference of the…